Results 51 to 60 of about 1,696,822 (255)
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
for mathematical biosciences · Volume 5 · Numbers 3/4
Mathematical Biosciences, 1970 exaly +2 more sources
Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction
Advanced Science, EarlyView.In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng +12 more
wiley +1 more source
Advanced Science, EarlyView.Controlled Pt–Pt fine structure in square‐planar Pt(II) complexes governs metal–metal‐to‐ligand charge‐transfer (MMLCT) state formation, exciton dynamics, and organic light‐emitting diode performance. Short Pt–Pt contacts in Pt(fppz)2 enable coherent metal–metal coupling, sub‐microsecond emission and an external quantum efficiency of 29%, whereas ...
Atul Shukla +15 more
wiley +1 more source
Advanced Science, EarlyView.A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang +6 more
wiley +1 more source
Netrin Signaling Defines the Regional Border in the Drosophila Visual Center
iScience, 2018 Summary: The brain consists of distinct domains defined by sharp borders. So far, the mechanisms of compartmentalization of developing tissues include cell adhesion, cell repulsion, and cortical tension.
Takumi Suzuki +9 more
doaj +1 more source
Evaluation of FRET X for single-molecule protein fingerprinting
iScience, 2021 Summary: Single-molecule protein identification is an unrealized concept with potentially ground-breaking applications in biological research. We propose a method called FRET X (Förster Resonance Energy Transfer via DNA eXchange) fingerprinting, in which
Carlos Victor de Lannoy +4 more
doaj +1 more source
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Blood Flow Contributions to Cancer Metastasis
iScience, 2020 Summary: The distribution patterns of cancer metastasis depend on a sequence of steps involving adhesion molecules and on mechanical and geometrical effects related to blood circulation, but how much each of these two aspects contributes to the ...
Francesc Font-Clos +2 more
doaj +1 more source
An opponent process for alcohol addiction based on changes in endocrine gland mass
iScience, 2021 Summary: Consuming addictive drugs is often initially pleasurable, but escalating drug intake eventually recruits physiological anti-reward systems called opponent processes that cause tolerance and withdrawal symptoms. Opponent processes are fundamental
Omer Karin, Moriya Raz, Uri Alon
doaj +1 more source