Results 71 to 80 of about 327,393 (318)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Potential health and economic impact of paediatric vaccination using next-generation influenza vaccines in Kenya: a modelling study

open access: yesBMC Medicine, 2023
Background Influenza is a major year-round cause of respiratory illness in Kenya, particularly in children under 5. Current influenza vaccines result in short-term, strain-specific immunity and were found in a previous study not to be cost-effective in ...
Naomi R. Waterlow   +9 more
doaj   +1 more source

On functional equations leading to exact solutions for standing internal waves [PDF]

open access: yes, 2016
The Dirichlet problem for the wave equation is a classical example of a problem which is ill-posed. Nevertheless, it has been used to model internal waves oscillating harmonically in time, in various situations, standing internal waves amongst them.
Keady, Grant   +4 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Riemann problem for multiply connected domain in Besov spaces

open access: yesBoundary Value Problems
In this paper, we obtain conditions of the solvability of the Riemann boundary value problem for sectionally analytic functions in multiply connected domains in Besov spaces embedded into the class of continuous functions.
Nazarbay Bliev, Nurlan Yerkinbayev
doaj   +1 more source

Bidirectional Encoder representation from Image Transformers for recognizing sunflower diseases from photographs

open access: yesКомпьютерная оптика
This paper proposes a modern system for recognizing sunflower diseases based on Bidirectional Encoder representation from Image Transformers (BEIT). The proposed system is capable of recognizing various sunflower diseases with high accuracy.
V.A. Baboshina   +3 more
doaj   +1 more source

The method of smelting metals from charge with low metal content in a furnace with bottom electrodes and the first laboratory studies

open access: yesMATEC Web of Conferences, 2018
Liquid phase smelting reduction process for utilization of ferrous waste in the electric furnace with stationary bottom electrodes by carbon-thermal reduction is proposed and tested in laboratory conditions.
Kazak Oleg, Starodumov Ilya
doaj   +1 more source

Anomalous Solute Transport in a Cylindrical Two-Zone Medium with Fractal Structure

open access: yesApplied Sciences, 2020
In this paper, a problem of anomalous solute transport in a coaxial cylindrical two-zone porous medium with fractal structure is posed and numerically solved.
Bakhtiyor Khuzhayorov   +3 more
doaj   +1 more source

A penalty method for PDE-constrained optimization in inverse problems [PDF]

open access: yes, 2016
Many inverse and parameter estimation problems can be written as PDE-constrained optimization problems. The goal is to infer the parameters, typically coefficients of the PDE, from partial measurements of the solutions of the PDE for several right-hand ...
Mathematical Modeling   +3 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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