Results 41 to 50 of about 907,841 (343)
Mathematical optimization in deep learning [PDF]
, 2019 Mathematical Optimization plays a pillar role in Machine Learning (ML) and Neural Networks (NN) are amongst the most popular and effective ML architectures and are the subject of a very intense investigation. They have also been proven immensely powerful
Ramírez Ayerbe, Miren Jasone
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Results in Control and Optimization, 2022 We propose a new three-term spectral conjugate gradient method via double direction approach by considering the first direction to be the one proposed by Halilu and Waziri (2018) and the other obtained by extending the direction proposed by Birgin and ...
Mohammed Yusuf Waziri +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Computation, 2021 In this study, a new methodology is proposed to perform optimal selection of conductors in three-phase distribution networks through a discrete version of the metaheuristic method of vortex search.
John Fernando Martínez-Gil +3 more
doaj +1 more source
Computer program for transient response of structural rings subjected to fragment impact [PDF]
, 1973 Mathematical optimization of containment/deflection system would save time, effort, and material as well as afford designer greater opportunity to investigate new ideas and variety of ...
Witmer, E. A., Wu, R. W.
core +1 more source
A Collection of Challenging Optimization Problems in Science, Engineering and Economics
, 2015 Function optimization and finding simultaneous solutions of a system of nonlinear equations (SNE) are two closely related and important optimization problems.
Grosan, Crina, Mehta, Dhagash
core +1 more source