Results 51 to 60 of about 907,841 (343)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

An L_1 then L_0 approach to the cardinality constrained mean-variance and mean-CVaR portfolio optimization problems [PDF]

Mathematics and Modeling in Finance
Cardinality constrained portfolio optimization problems are widely used portfolio optimization models which incorporate restriction on the number of assets in the portfolio.
Maziar Salahi, Tahereh Khodamoradi
doaj   +1 more source

Using Functional Programming to recognize Named Structure in an Optimization Problem: Application to Pooling [PDF]

, 2016
Branch-and-cut optimization solvers typically apply generic algorithms, e.g., cutting planes or primal heuristics, to expedite performance for many mathematical optimization problems.
Ceccon, F, Kouyialis, G, Misener, R
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Mathematical Modeling and Nonlinear Optimization in Determining the Minimum Risk of Legalization of Income from Criminal Activities in the Context of EU Member Countries

Mathematics, 2022
Legalization of the proceeds of crime represents a worldwide problem with serious economic and social consequences. Information technologies in conjunction with advanced computer techniques are important tools in the fight against money laundering (ML ...
Alena Vagaská, Miroslav Gombár, Antonín Korauš   +2 more
doaj   +1 more source

Association of CDKN2A/B Homozygous Deletion and Extent of Resection With Survival of Patients With WHO CNS5 Grade 4 Astrocytoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives WHO grade 4 astrocytomas are associated with poor prognosis, and their prognostic factors remain controversial. This study aimed to identify the prognostic factors and develop a management algorithm for these patients. Methods This study retrospectively included 151 CNS5 adult grade 4 astrocytomas from two medical centers.
Jiawei Cai, Guanglin Zhu, Qiu He, Chen Luo, Lingyun Zhuo, Xingfu Wang, Yiming Chen, Xiaoyong Chen, Wendong You, Jiaheng Xu, Yuanxiang Lin, Dezhi Kang, Shuai Wu, Zanyi Wu   +13 more
wiley   +1 more source

Optimal Integration of Dispersed Generation in Medium-Voltage Distribution Networks for Voltage Stability Enhancement

Algorithms, 2022
This study addresses the problem of the maximization of the voltage stability index (λ-coefficient) in medium-voltage distribution networks considering the optimal placement and sizing of dispersed generators.
Brayan Enrique Aguirre-Angulo, Lady Carolina Giraldo-Bello, Oscar Danilo Montoya, Francisco David Moya   +3 more
doaj   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Application of the Crow Search Algorithm to the Problem of the Parametric Estimation in Transformers Considering Voltage and Current Measures

Computers, 2022
The problem of the electrical characterization of single-phase transformers is addressed in this research through the application of the crow search algorithm (CSA).
David Gilberto Gracia-Velásquez, Andrés Steven Morales-Rodríguez, Oscar Danilo Montoya   +2 more
doaj   +1 more source

Maximizing expected utility in the Arbitrage Pricing Model [PDF]

, 2017
We consider an infinite dimensional optimization problem motivated by mathematical economics. Within the celebrated "Arbitrage Pricing Model", we use probabilistic and functional analytic techniques to show the existence of optimal strategies for ...
Rasonyi, Miklos
core   +2 more sources