Results 121 to 130 of about 1,003,903 (269)
Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery
Advanced Science, EarlyView.Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
Jurnal DerivatThis article discusses the analysis of learning obstacles among students in mathematical induction proof. Mathematical induction proof is a crucial topic in developing students' logical and problem-solving skills, but many students face obstacles in ...
wildatus sholihah
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Smart Optogenetics for Real‐Time Automated Control of Cardiac Electrical Activity
Advanced Science, EarlyView.We are able to stop dangerous heart‐rhythm spirals before they fully form. Within about 100 ms, it pinpoints the spiral's tiny central tip (≈0.9 mm) using light‐based sensing and machine learning, then shines targeted light to shut it down. This fast, precise, closed‐loop approach detects, targets, and terminates arrhythmias in real time.
Shanliang Deng +15 more
wiley +1 more source
Acceptable gaps in mathematical proofs
Synthese, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Advanced Science, EarlyView.A conditional multi‐task deep learning framework is developed for designing and optimizing Full‐Stokes Hyperspectro‐Polarimetric Encoding Metasurfaces (FHPEMs). This framework achieves joint spectro‐polarimetric learning and unified forward–inverse design.
Chenjie Gong +9 more
wiley +1 more source
Mathematical proofs in practice: revisiting the reliability of published mathematical proofs
, 2014 Mathematics seems to have a special status when compared to other areas of human knowledge. This special status is linked with the role of proof. Mathematicians often believe that this type of argumentation leaves no room for errors and unclarity. Philosophers of mathematics have differentiated between absolutist and fallibilist views on mathematical ...
Frans, Joachim, Kosolosky, Laszlo
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Advanced Science, EarlyView.This review examines the evolution of bioprinting toward minimally invasive in situ strategies for internal organ regeneration. It defines the technological roadmap from handheld systems to advanced minimally invasive bioprinting platforms, positioning soft robotics as a core enabler.
Duc Tu Vu +9 more
wiley +1 more source
Advanced Science, EarlyView.Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong +21 more
wiley +1 more source
Advanced Science, EarlyView.The adsorption of AsV on akaganeite nanorods was found to provide a magnetic signature. A change in the surface spin order gave rise to a second peak in the zero‐field cooled curve. AsIII adsorption does not provide any change in the magnetic behavior of the sorbent.
Marco Sanna Angotzi +11 more
wiley +1 more source
Rozumienie dowodu matematycznego a zagadnienie wyjaśnienia w matematyce
Zagadnienia Filozoficzne w Nauce, 2015 In the article, I present two possible points of view concerning mathematical proofs: (a) the formal view (according to which the formalized versions of mathematical proofs reveal their “essence”); (b) the semantic view (according to which mathematical ...
Krzysztof Wójtowicz
doaj