Results 31 to 40 of about 3,239,824 (259)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Bayesian Accelerated Failure Time Model for Zero-Inflated Survival Data With Application to Liver Cirrhosis

open access: yesJournal of Probability and Statistics
Analyzing count data, particularly in survival analysis, is challenging when there are many zeros, and some observations are right-censored. This study tackles zero-inflated survival event data (ZISED), specifically focusing on liver cirrhosis cases in ...
Peter Enesi Omaku   +2 more
doaj   +1 more source

Risk estimation in the thinly traded JSE environment

open access: yesSouth African Journal of Business Management, 1989
Received evidence has come to the fore which suggests that the major source of bias in the estimation of beta coefficients on the JSE can be attributable to the thinly traded phenomenon.
D. J. Bradfield, G. D.I. Barr
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Error bounds of block sparse signal recovery based on q-ratio block constrained minimal singular values

open access: yesEURASIP Journal on Advances in Signal Processing, 2019
In this paper, we introduce the q-ratio block constrained minimal singular values (BCMSV) as a new measure of measurement matrix in compressive sensing of block sparse/compressive signals and present an algorithm for computing this new measure.
Jianfeng Wang, Zhiyong Zhou, Jun Yu
doaj   +1 more source

Basics of modern mathematical statistics

open access: yes, 2015
This textbook provides a unified and self-contained presentation of the main approaches to and ideas of mathematical statistics. It collects the basic mathematical ideas and tools needed as a basis for more serious studies or even independent research in
Spokoiny, Vladimir, Dickhaus, Thorsten
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

open access: yesFEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh   +2 more
wiley   +1 more source

Impact of two relaxation times on thermal, P and SV waves at interface with magnetic field and temperature dependent elastic moduli

open access: yesResults in Physics, 2018
In this article, two models of the generalized thermo-elastic theory are used to see the influence on the refraction and reflection of the plane waves at the interface under a constant magnetic field.
Ambreen Asfar Khan   +2 more
doaj   +1 more source

Why distinguish between statistics and mathematical statistics - the case of Swedish academia [PDF]

open access: yes, 2016
A separation between the academic subjects statistics and mathematical statistics has existed in Sweden almost as long as there have been statistics professors. The same distinction has not been maintained in other countries.
Lindgren, Georg, Guttorp, Peter
core  

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova   +9 more
wiley   +1 more source

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