Results 51 to 60 of about 2,101,144 (285)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Analysis of Rattleback Chaotic Oscillations

The Scientific World Journal, 2014
Rattleback is a canoe-shaped object, already known from ancient times, exhibiting a nontrivial rotational behaviour. Although its shape looks symmetric, its kinematic behaviour seems to be asymmetric.
Michael Hanias, Stavros G. Stavrinides, Santo Banerjee   +2 more
doaj   +1 more source

Contribution to understanding the mathematical structure of quantum mechanics

, 2006
Probabilistic description of results of measurements and its consequences for understanding quantum mechanics are discussed. It is shown that the basic mathematical structure of quantum mechanics like the probability amplitudes, Born rule, commutation ...
A. Bohr, A. E. Allahverdyan, A. Landé, A. S. Davydov, A. Zeilinger, A. Zeilinger, A. Zeilinger, B. Roy Frieden, Brukner, D. Bohm, D. Bohm, D. Bohm, D. C. Brody, D. I. Fivel, D. N. Klyshko, E. Madelung, F. H. Fröhner, F. Laloé, G. Birkhoff, G. Ludwig, H. Everett III, J. G. Cramer, J. Hilgerwood, J.A. Wheeler, L. Skala, L. Skála, M. Arndt, M. Born, M. O. Scully, M. Reginatto, O. Hay, P. Busch, R. A. Fisher, R. P. Feynman, R. Shankar, S. L. Braunstein, S. M. Roy, T. Cover, V. Kapsa, W. E. Lamb, W. Heisenberg   +40 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Connecting With Fundamental Mathematical Knowledge Directly: The Organizational Features of Good Mathematical Cognitive Structure

Frontiers in Psychology, 2018
This paper reported on the study of a good mathematical cognitive structure (GMCS) based on 43 top university students and 82 concepts of Calculus materials, using the social network analysis method.
Zezhong Yang, Yanqing Zhang, Kai Wang, Ming Zhu   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

On mathematical structure of effective observables [PDF]

Journal of Mathematical Physics, 2001
We decompose the Hilbert space of wave functions into two subspaces, and assign to a given observable two effective representatives that act in the model space. The first serves to determine some of the eigenvalues of the full observable, while the second serves to determine its matrix elements, in any basis in one of the subspaces, in terms of ...
Viazminsky, C. P., Vary, James P.
openaire   +2 more sources

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source