Results 21 to 30 of about 66,626 (268)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Invariant metrics and complex geodesics in several complex variables - [PDF]

open access: yes, 2015
Thesis. M.S. American University of Beirut. Department of Mathematics, 2015. T:6365Advisor : Dr. Florian Bertrand, Assistant Professor, Mathemtics ; Members of Committee : Dr. Faruk Abi-Khuzam, Professor, Mathematics ; Dr.
Mrad, Preskella Mounir,
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Several complex variables and complex manifolds II

open access: yes, 1982
This self-contained and relatively elementary introduction to functions of several complex variables and complex (especially compact) manifolds is intended to be a synthesis of those topics and a broad introduction to the field.
Mike Field, Field, Mike
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Lectures on several complex variables

open access: yes, 2014
This monograph provides a concise, accessible snapshot of key topics in several complex variables, including the Cauchy Integral Formula, sequences of holomorphic functions, plurisubharmonic functions, the Dirichlet problem, and meromorphic functions ...
Gauthier, Paul M
core   +1 more source

Barrlund's distance function and quasiconformal maps [PDF]

open access: yes, 2022
Answering a question about triangle inequality suggested by R. Li, Barrlund [The p-relative distance is a metric. SIAM J Matrix Anal Appl. 1999;21:699.702] introduced a distance function which is a metric on a subdomain of We study this Barrlund metric ...
Vuorinen M, Mocanu M, Fujimura M
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Angular derivatives in several complex variables

open access: yes, 2004
We describe a general procedure for studying the boundary behavior of holomorphic maps in several complex variables at a specific point in the boundary, and for proving Lindelof principles and Julia-Wolff-Carathéodory theorems.
ABATE, MARCO, Marco Abate
core   +1 more source

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