Results 21 to 30 of about 2,752,382 (159)
PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential
Cytoskeleton, EarlyView.ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah +2 more
wiley +1 more source
Traditional Chinese Medicine Properties and Microcalorimetry: BioScience Evaluation
Med Research, EarlyView.ABSTRACT The properties theory of traditional Chinese medicine (TCM), characterized by cold, hot, warm, and cool four properties, is fundamental to its development, distinguishing it from natural, botanical, and chemical medicines. However, despite its significance, there is no unified theoretical definition, bioscientific characterization, or ...
Qiang Li +9 more
wiley +1 more source
PROTEOMICS, EarlyView.ABSTRACT Chronic kidney disease (CKD) poses a significant and growing global health challenge, making early detection and slowing disease progression essential for improving patient outcomes. Traditional diagnostic methods such as glomerular filtration rate and proteinuria are insufficient to capture the complexity of CKD.
Marta B. Lopes +9 more
wiley +1 more source
Topology of random simplicial complexes: a survey
, 2013 This expository article is based on a lecture from the Stanford Symposium on Algebraic Topology: Application and New Directions, held in honor of Gunnar Carlsson, Ralph Cohen, and Ib Madsen.Comment: After revisions, now 21 pages, 5 ...
Kahle, Matthew
core +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Protein crystallization remains a major bottleneck in X‐ray crystallography due to difficulties in achieving favorable molecular arrangements within the crystal lattice. While protein–protein interactions at molecular packing interfaces are crucial for determining crystallization conditions, methods for predicting crystal packing interfaces ...
Kuan‐Ju Liao, Yuh‐Ju Sun
wiley +1 more source
Advanced Quantum Technologies, EarlyView.The hybrid approach to Quantum Supervised Machine Learning is compatible with Noisy Intermediate Scale Quantum (NISQ) devices but hardly useful. Pure quantum kernels requiring fault‐tolerant quantum computers are more promising. Examples are kernels computed by means of the Quantum Fourier Transform (QFT) and kernels defined via the calculation of ...
Massimiliano Incudini +2 more
wiley +1 more source
Universality of K-Theory [PDF]
, 2013 We prove that graded K-theory is universal among oriented Borel-Moore homology theories with a multiplicative periodic formal group law.Comment: 12 ...
González, José Luis, Karu, Kalle
core
Threshold Concepts and Concept Networks in Evolution Education: An Experimental Intervention Study
Science Education, EarlyView.ABSTRACT This study analyzes the effect of different instructions on threshold concepts within material covering natural selection on students' use of concepts about evolution. Moreover, it examines students' use of concepts as interconnected networks when reasoning about natural selection and analyzes how these concepts relate to each other regarding ...
Helena Aptyka +2 more
wiley +1 more source
A factorization homology primer [PDF]
arXiv, 2019 This chapter amalgamates some foundational developments and calculations in factorization homology.
arxiv
Small, EarlyView.This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai +5 more
wiley +1 more source