Results 41 to 50 of about 61,144 (126)

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient

The Journal of Physiology, EarlyView.
Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo, Zachary D. Long, Arie O. Verkerk, Jose M. Ferrero, T. Alexander Quinn, Jose F. Rodriguez Matas   +5 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Spatial analysis of cell patterning to aid genetic and phenotypic understanding of grass stomatal density: A case study in maize

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Biological processes involve complex hierarchies where composite traits result from multiple component traits. However, holistically understanding of how sets of component traits interact to underpin genotype‐to‐phenotype relationships is generally lacking.
John G. Hodge, Andrew D. B. Leakey
wiley   +1 more source

Topological Graph Neural Networks: A Novel Approach for Geometric Deep Learning

Applied AI Letters, Volume 7, Issue 2, June 2026.
This graphical abstract illustrates the Topological Graph Neural Network (TopGNN) architecture. It demonstrates a parallel processing approach where an input graph is simultaneously analyzed by a standard GNN Encoder to capture local node features and by Persistent Homology to extract global topological features (like cycles and voids), visualized as a
Amarjeet, Anurag Sinha, Khalid Hussain, Wasim Ahmad Bhat, Sudhanshu Maurya, Mohammad Nadeem Ahmed, Mohammad Rashid Hussain, S. Khalid   +7 more
wiley   +1 more source

Opportunities and challenges in protein structure prediction

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Deep learning methods, particularly exemplified by AlphaFold2, have revolutionized the field of protein structure prediction—an achievement recognized by the 2024 Nobel Prize in Chemistry awarded to its core developers. Despite this remarkable achievement, the broader protein folding problem is far from solved. Key challenges—each representing
Wenkai Wang, Baoquan Su, Chenxiao Xiang, Jianyi Yang   +3 more
wiley   +1 more source

Coulomb branch algebras via symplectic cohomology

Journal of Topology, Volume 19, Issue 2, June 2026.
Abstract Let (M¯,ω)$(\bar{M}, \omega)$ be a compact symplectic manifold with convex boundary and c1(TM¯)=0$c_1(T\bar{M})=0$. Suppose that (M¯,ω)$(\bar{M}, \omega)$ is equipped with a convex Hamiltonian G$G$‐action for some connected, compact Lie group G$G$.
Eduardo González, Cheuk Yu Mak, Dan Pomerleano   +2 more
wiley   +1 more source

Infinity‐operadic foundations for embedding calculus

Journal of Topology, Volume 19, Issue 2, June 2026.
Abstract Motivated by applications to spaces of embeddings and automorphisms of manifolds, we consider a tower of ∞$\infty$‐categories of truncated right modules over a unital ∞$\infty$‐operad O$\mathcal {O}$. We study monoidality and naturality properties of this tower, identify its layers, describe the difference between the towers as O$\mathcal {O}$
Manuel Krannich, Alexander Kupers
wiley   +1 more source

Degree theory for 4‐dimensional asymptotically conical gradient expanding solitons

Communications on Pure and Applied Mathematics, Volume 79, Issue 5, Page 1151-1298, May 2026.
Abstract We develop a new degree theory for 4‐dimensional, asymptotically conical gradient expanding solitons. Our theory implies the existence of gradient expanding solitons that are asymptotic to any given cone over S3$S^3$ with non‐negative scalar curvature. We also obtain a similar existence result for cones whose link is diffeomorphic to S3/Γ$S^3/\
Richard H. Bamler, Eric Chen
wiley   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Absolute quantification of fluorescent protein fusions by mass spectrometry

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Fusions with fluorescent proteins (FPs) play a pivotal role in experimental biology because of their sensitive and spatially precise visualization by spectroscopy. However, observed fluorescence is not always proportional to their molar concentration.
Anna Shevchenko, Archishman Ghosh, Andrea Schuhmann, Aliona Bogdanova, Henrik Thomas, Viditha Rao, Eric R. Geertsma, T.‐Y. Dora Tang, Andrej Shevchenko   +8 more
wiley   +1 more source