Results 51 to 60 of about 61,144 (126)
Abstract Intrinsically disordered regions (IDRs) play important molecular roles in cells even though they do not adopt a stable structure. Relative to structured regions, IDRs have skewed amino acid compositions favoring polar and charged amino acids. This feature is a major contributor to the biophysical behavior and in vivo activity of IDRs, but the ...
Sean M. Cascarina +3 more
wiley +1 more source
General formulas are presented that allow for the enumeration of polytypes based on translationally equivalent layers and two equivalent arrangements of adjacent layers involving distinct possible stacking vectors, t1 and t2. The results have been applied to the polytypism among two different polysomes of the family of so‐called silico‐ferrites of ...
Michael Francesco Salzmann +3 more
wiley +1 more source
This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe +5 more
wiley +2 more sources
We developed a LASSO‐based approach to uncover a three‐layered “fan‐in fan‐out” network architecture for complex traits like yeast aging, showing that peripheral genes influence lifespan indirectly through master regulators, which converge on core functional modules (e.g., stress response, autophagy).
Meng Ma +12 more
wiley +1 more source
We explore a topological model that situates teachers' agency as a constituent element within the convergent and divergent dynamics at the intersection of human‐mediated and algorithmically mediated pedagogies. Ubiquitous AI in education is designed to simulate, emulate and automate human processes and behaviours through datafication.
Keith Turvey, Norbert Pachler
wiley +1 more source
ABSTRACT While the heterogeneity and co‐occurrence of heritable neurodevelopmental conditions such as autism, attention deficit hyperactivity disorder (ADHD), and dyslexia remain issues of debate, these conditions are nevertheless all characterised by uneven cognitive profiles exhibiting strengths and weaknesses.
Maitrei Kohli +2 more
wiley +1 more source
Advances and opportunities for computational interrogation of plant proteins
SUMMARY Plants exhibit remarkable biochemical and physiological diversity, and are capable of adapting to a wide range of environmental conditions and stresses. This complexity makes them essential systems for understanding how life responds to a changing climate.
Sarah M. Bohling +2 more
wiley +1 more source
A note on relative Gelfand–Fuks cohomology of spheres
Abstract We study the Gelfand–Fuks cohomology of smooth vector fields on Sd$\mathbb {S}^d$ relative to SO(d+1)$\mathrm{SO}(d+1)$ following a method of Haefliger that uses tools from rational homotopy theory. In particular, we show that H∗(BSO(4);R)$H^*(\mathrm{B}\mathrm{SO}(4);\mathbb {R})$ injects into the relative Gelfand–Fuks cohomology which ...
Nils Prigge
wiley +1 more source
Stabilization of Poincaré duality complexes and homotopy gyrations
Abstract Stabilization of manifolds by a product of spheres or a projective space is important in geometry. There has been considerable recent work that studies the homotopy theory of stabilization for connected manifolds. This paper generalizes that work by developing new methods that allow for a generalization to stabilization of Poincaré duality ...
Ruizhi Huang, Stephen Theriault
wiley +1 more source
Bulky residues constrict the central pore of WT SoPIP2;1, generating high energy barriers for both O2 and CO2 and preventing gas permeation. ABSTRACT Aquaporins (AQPs) are classical water channels that also conduct small gas molecules such as O2$$ {\mathrm{O}}_2 $$ and CO2$$ {\mathrm{CO}}_2 $$ across the membrane.
Ahmad Raeisi Najafi +5 more
wiley +1 more source

