Results 51 to 60 of about 2,752,382 (159)

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin   +7 more
wiley   +1 more source

A Sharper Ramsey Theorem for Constrained Drawings

open access: yesJournal of Graph Theory, Volume 109, Issue 4, Page 401-411, August 2025.
ABSTRACT Given a graph G and a collection C of subsets of R d indexed by the subsets of vertices of G, a constrained drawing of G is a drawing where each edge is drawn inside some set from C, in such a way that nonadjacent edges are drawn in sets with disjoint indices. In this paper we prove a Ramsey‐type result for such drawings.
Pavel Paták
wiley   +1 more source

Computing Invariants of Simplicial Manifolds

open access: yes, 2004
This is a survey of known algorithms in algebraic topology with a focus on finite simplicial complexes and, in particular, simplicial manifolds. Wherever possible an elementary approach is chosen.
Joswig, Michael
core   +1 more source

Molecular Dynamics Simulations of a Putative Novel Mechanism for UCP1‐Assisted FA Anion Transport

open access: yesActa Physiologica, Volume 241, Issue 7, July 2025.
ABSTRACT Background Mitochondrial energy can be stored as ATP or released as heat by uncoupling protein 1 (UCP1) during non‐shivering thermogenesis in brown adipose tissue. UCP1, located in the inner mitochondrial membrane, reduces the proton gradient in the presence of long‐chain fatty acids (FA).
Sanja Vojvodić   +3 more
wiley   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison   +15 more
wiley   +1 more source

Development of a New AMBER Force Field for Cysteine and Histidine Cadmium‐Binding Proteins and Its Validation Through QM/MM MD Simulations

open access: yesJournal of Computational Chemistry, Volume 46, Issue 16, June 15, 2025.
In the context of the AMBER parameterization, a new force field is developed and validated for the simulation of cadmium(II)‐binding proteins. The proposed force field takes into account the polarization effect produced by the central ion on its surroundings.
Matteo Orlandi   +5 more
wiley   +1 more source

Model structure on projective systems of $C^*$-algebras and bivariant homology theories

open access: yes, 2017
Using the machinery of weak fibration categories due to Schlank and the first author, we construct a convenient model structure on the pro-category of separable $C^*$-algebras $\mathrm{Pro}(\mathtt{SC^*})$. The opposite of this model category models the $
Barnea, Ilan   +2 more
core  

Lectures on the triangulation conjecture

open access: yes, 2016
We outline the proof that non-triangulable manifolds exist in any dimension greater than four. The arguments involve homology cobordism invariants coming from the Pin(2) symmetry of the Seiberg-Witten equations. We also explore a related construction, of
Manolescu, Ciprian
core  

Exploring the Latent Information in Spatial Transcriptomics Data via Multi‐View Graph Convolutional Network Based on Implicit Contrastive Learning

open access: yesAdvanced Science, Volume 12, Issue 21, June 5, 2025.
STMIGCL is an implicit contrastive learning‐based multi‐view graph convolutional network framework designed for downstream tasks such as spatial domain recognition, trajectory inference, and spatially variable gene identification. By combining multi‐view learning with contrastive learning and employing contrastive learning methods that enhance contrast
Sheng Ren   +5 more
wiley   +1 more source

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