Results 21 to 30 of about 34,142 (266)

Mathematical Modeling and Optimal Control of Complex Epidemiological Networks [PDF]

, 2021
An optimal strategy for controlling the dynamics of a multi-scale complex network of epidemiological models is investigated. We focus on the chikungunya epidemic and consider the spreading of the disease within an indigenous urban region contaminated after the transmission of the virus to the local vectorial fauna by a single human individual.
Cantin, Guillaume, Verdière, Nathalie
openaire   +3 more sources

Linear Operator Inequality and Null Controllability with Vanishing Energy for Unbounded Control Systems [PDF]

, 2013
We consider a linear boundary or point control system on a Hilbert space $H$ which is null controllable at some time $T_0 >0$. To every initial state $ y_0 \in H$ we associate the minimal ``energy'' needed to transfer $ y_0 $ to $ 0 $ in a time $ T \ge ...
Zabczyk, J., Enrico Priola, Priola E., Luciano Pandolfi, Jerzy Zabczyk, Zabczyk J., Priola, E., Pandolfi, Luciano   +7 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

HIGH SPEED FUNCTIONALITY OPTIMIZATION OF FIVE-PHASE PM MACHINE USING 3RD HARMONIC CURRENT [PDF]

, 2013
This project was supported by the Laboratory of Electrical Engineering and Power Electronics (L2EP) France. It is a successive cooperation project between the control team and optimization team of the laboratory .Some surrogate-assisted optimization ...
GONG, Jinlin, ASLAN, Bassel, SEMAIL, Eric, GONG, Jilin, GILLON, Frédéric   +4 more
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Mathematical Model for Optimal Control of Soil-Transmitted Helminth Infection [PDF]

Computational and Mathematical Methods in Medicine, 2020
In this paper, we study the dynamics of soil-transmitted helminth infection. We formulate and analyse a deterministic compartmental model using nonlinear differential equations. The basic reproduction number is obtained and both disease-free and endemic equilibrium points are shown to be asymptotically stable under given threshold conditions. The model
Aristide G. Lambura, Gasper Godson Mwanga, Livingstone S. Luboobi, Dmitry Kuznetsov   +3 more
openaire   +3 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Constrained Estimation and Approximation Using Control, Optimization, and Spline Theory

, 2016
There has been an increasing interest in shape constrained estimation and approximation in the fields of applied mathematics and statistics. Applications from various areas of research such as biology, engineering, and economics have fueled this soaring ...
Lebair, Teresa M.
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Search space pruning and global optimization of multiple gravity assist trajectories with deep space manoeuvres

, 2007
This paper deals with the design of optimal multiple gravity assist trajectories with deep space manoeuvres. A pruning method which considers the sequential nature of the problem is presented.
M. Ceriotti, Becerra, Victor M., Nasuto, S. J., Nasuto, S.J., C. Bombardelli, Anderson, J., Bombardelli, C., Ceriotti, M., Anderson, James D., Becerra, V.M., Nasuto, Slawomir J., V.M. Becerra, Becerra, V. M., S.J. Nasuto, J. Anderson, Bombardelli, Claudio   +15 more
core   +1 more source