Results 41 to 50 of about 42,507 (261)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Mathematical Model for Optimal Control of Soil-Transmitted Helminth Infection [PDF]
Computational and Mathematical Methods in Medicine, 2020 In this paper, we study the dynamics of soil-transmitted helminth infection. We formulate and analyse a deterministic compartmental model using nonlinear differential equations. The basic reproduction number is obtained and both disease-free and endemic equilibrium points are shown to be asymptotically stable under given threshold conditions. The model
Aristide G. Lambura +3 more
openaire +3 more sources
Linear Operator Inequality and Null Controllability with Vanishing Energy for Unbounded Control Systems [PDF]
, 2013 We consider a linear boundary or point control system on a Hilbert space $H$ which is null controllable at some time $T_0 >0$. To every initial state $ y_0 \in H$ we associate the minimal ``energy'' needed to transfer $ y_0 $ to $ 0 $ in a time $ T \ge ...
Zabczyk, J. +8 more
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Control, Optimization, and Mathematical Modeling of Complex Systems
, 2023 Complex systems have long been an integral part of modern life and can be encountered everywhere. Undertaking a comprehensive study of such systems is a challenging problem, one which is impossible to solve without the use of contemporary mathematical ...
core +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Optimal stochastic control and carbon price formation
, 2009 10.1137/080736910SIAM Journal on Control and Optimization4842168 ...
Fehr, M. +8 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau +11 more
wiley +1 more source
Journal of Numerical Mathematics
, 2014 The Journal of Numerical Mathematics (formerly East-West Journal of Numerical Mathematics) contains high-quality papers featuring contemporary research in all areas of Numerical Mathematics.
SIMONCINI, VALERIA
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Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source