Results 61 to 70 of about 26,323 (148)

Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System

open access: yesAdvanced Science, EarlyView.
This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao   +7 more
wiley   +1 more source

Electronic Structure of Kramers Nodal‐Line Semimetal YAuGe and Anomalous Hall Effect Induced by Magnetic Rare‐Earth Substitution

open access: yesAdvanced Science, EarlyView.
The rare‐earth intermetallics YAuGe is identified as a Kramers nodal‐line semimetal, a topological state inherent to non‐centrosymmetric achiral lattices. Magnetic rare‐earth substitution induces an anomalous Hall effect, highlighting the impact of time‐reversal symmetry breaking on topological electronic states and offering insights into designing the
Takashi Kurumaji   +13 more
wiley   +1 more source

Secondary Electron Hyperspectral Imaging of Carbons: New Insights and Good Practice Guide

open access: yesAdvanced Science, EarlyView.
Secondary hyperspectral imaging of carbon surfaces is assessed with reference materials and in comparison to standard spectroscopies. Characterization of functional carbon materials from battery research reveals otherwise inaccessible information about the distribution of sp2 and amorphous carbon, as shown in graphite anode and carbon coated lithium ...
James F. Nohl   +22 more
wiley   +1 more source

Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment

open access: yesAdvanced Science, EarlyView.
A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen   +9 more
wiley   +1 more source

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