Results 41 to 50 of about 66,175 (254)

What Role Might Non-Mating Receptors Play in Schizophyllum commune?

Journal of Fungi, 2021
The B mating-type locus of the tetrapolar basidiomycete Schizophyllum commune encodes pheromones and pheromone receptors in multiple allelic specificities.
Sophia Wirth, Daniela Freihorst, Katrin Krause, Erika Kothe   +3 more
doaj   +1 more source

Hungry for Sex: Differential Roles for Ustilago maydisb Locus Components in Haploid Cells vis à vis Nutritional Availability

Journal of Fungi, 2021
Mating-types allow single-celled eukaryotic organisms to distinguish self from non-self in preparation for sexual reproduction. The components of mating-type loci provide initial self/non-self-recognition through pheromone and receptor interactions that ...
R. Margaret Wallen, Kirsten Richardson, Madison Furnish, Hector Mendoza, Allison Dentinger, Sunita Khanal, Michael H. Perlin   +6 more
doaj   +1 more source

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Uncovering the history of recombination and population structure in western Canadian stripe rust populations through mating type alleles

BMC Biology, 2023
Background The population structure of crop pathogens such as Puccinia striiformis f. sp. tritici (Pst), the cause of wheat stripe rust, is of interest to researchers looking to understand these pathogens on a molecular level as well as those with an ...
Samuel Holden, Guus Bakkeren, John Hubensky, Ramandeep Bamrah, Mehrdad Abbasi, Dinah Qutob, Mei-Lan de Graaf, Sang Hu Kim, Hadley R. Kutcher, Brent D. McCallum, Harpinder S. Randhawa, Muhammad Iqbal, Keith Uloth, Rishi R. Burlakoti, Gurcharn S. Brar   +14 more
doaj   +1 more source

Genetic Structure of the Mating-Type Locus of Chlamydomonas reinhardtii

Genetics, 2002
Abstract Portions of the cloned mating-type (MT) loci (mt+ and mt−) of Chlamydomonas reinhardtii, defined as the ~1-Mb domains of linkage group VI that are under recombinational suppression, were subjected to Northern analysis to elucidate their coding capacity.
Patrick J, Ferris, E Virginia, Armbrust, Ursula W, Goodenough   +2 more
openaire   +2 more sources

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

A SUPPRESSOR OF MATING-TYPE LOCUS MUTATIONS IN SACCHAROMYCES CEREVISIAE: EVIDENCE FOR AND IDENTIFICATION OF CRYPTIC MATING-TYPE LOCI [PDF]

Genetics, 1979
ABSTRACT A mutation has been identified that suppresses the mating and sporulation defects of all mutations in the mating-type loci of S. cereuisiae. This suppressor, sir1-1, restores mating ability to matαl and matα2 mutants and restores sporulation ability to matα2 and mata1 mutants.
J, Rine, J N, Strathern, J B, Hicks, I, Herskowitz   +3 more
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Healing of mat mutations and control of mating type interconversion by the mating type locus in Saccharomyces cerevisiae [PDF]

Proceedings of the National Academy of Sciences, 1979
Homothallic yeasts switch cell types (mating types a and α) at high frequency by changing the alleles of the mating type locus, MAT a and MAT α. We have proposed in the cassette model that yeast cells contain silent MAT
J N, Strathern, L C, Blair, I, Herskowitz   +2 more
openaire   +2 more sources