Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Polarization‐Dependent and Color‐Tunable Electrochromic Smart Windows: Uniaxially Oriented and Polymer‐Stabilized Viologen‐Based Liquid Crystal Networks (Adv. Funct. Mater. 39/2024) [PDF]
Huan Huu Pham +9 more
openalex +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Lithium Anodes: An Anion‐Tuned Solid Electrolyte Interphase with Fast Ion Transfer Kinetics for Stable Lithium Anodes (Adv. Energy Mater. 14/2020) [PDF]
, 2020 Zhenxing Wang +7 more
openalex +1 more source
Anisotropic friction and wear of single-crystal manganese-zinc ferrite in contact with itself [PDF]
Sliding friction experiments were conducted with manganese-zinc ferrite (100), (110), (111), and (211) planes in contact with themselves. Mating the highest-atomic-density directions, (110), of matched crystallographic planes resulted in the lowest ...
Buckley, D. H., Miyoshi, K.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Changes in educational assortative mating in contemporary Spain [PDF]
This article analyses patterns and trends in educational assortative mating of the Spanish women born between 1920 and 1969 using data from the 2001 Spanish Census. By means of loglinear models we examine the following issues: i) intensity and changes in
Albert Esteve, Clara Cortina
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Education Level and Mating Success: Undercover on Tinder
, 2018 Brecht Neyt +2 more
openalex +1 more source