Results 81 to 90 of about 52,841 (278)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
International Journal of Horticultural Science, 2007 The study was aimed to study that how mating disruption by hand applied dispensers can reduce the number of damage caused by Cydia pomonella, Adoxophyes orana and Pandemis heparana in four integrated and organic apple orchards.
I. Újvári, I. J. Holb
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
California Agriculture, 1993 In flight, codling moths prefer upper tree strata, whereas navel orangeworm oviposition is more evenly distributed throughout the tree. Pest monitoring and pheromone placement for mating disruption should recognize the vertical distribution of these ...
G. Steven Sibbett +4 more
doaj +3 more sources
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Mating disruption of Lobesia botrana (Lepidoptera: Tortricidae) in vineyards with very high population densities. [PDF]
, 2001 : Two tortricids, Lobesia botrana and Eupoecilia ambiguella, are the most important insect pests in German viticulture. Both species are bivoltine and the second generation is the most damaging to grapes.
Karl-Josef Schirra, Friedrich Louis
core
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Disruption of moth mating behaviour by olfactory and auditory cues [PDF]
, 2002 The impact of olfactory and auditory cues on the mating behaviour in two species of moths, Agrotis segetum (Noctuidae) and Plodia interpunctella (Pyralidae), was investigated to evaluate their potential use in integrated pest management.
Svensson, Glenn
core
Pheromone mating disruption offers selective management options for key pests
California Agriculture, 2005 The direct management of insect pests using pheromones for mating disruption, or “attract and kill” approaches, can provide excellent suppression of key lepidopteran pests in agriculture. Important successes to date include codling moth
Stephen Welter +5 more
doaj +2 more sources