Results 141 to 150 of about 221,203 (298)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Genetic and Molecular Evidence of a Tetrapolar Mating System in the Edible Mushroom Grifola frondosa. [PDF]

J Fungi (Basel), 2023
Zhang SS, Li X, Li GJ, Huang Q, Tian JH, Wang JL, Li M, Li SM.   +7 more
europepmc   +1 more source

Plasticity in plant mating systems

Trends in Plant Science
Many plants are extremely plastic in their vegetative and life-history traits, allowing them to deal with a variety of environmental conditions during their lifetime. However, in our understanding of plant reproduction, plasticity in mating system is not broadly considered. Even though mating system shifts are well studied on an evolutionary timescale,
Suijkerbuijk, Hanneke A.C., Ramos, Sergio E., Poelman, Erik H.   +2 more
openaire   +3 more sources

Mating system data organized by genus

, 2015
For each genus in the study there is a unique file "genus.csv" that contains the following data columns: species names (species), mating system category (mate.sys), method used to assign mating system (method), source (ref), notes (notes), and ...
Dena Grossenbacher (3251184), Yaniv Brandvain (458123), Grossenbacher, Dena, Emma E. Goldberg (672137), Goldberg, Emma E., Brandvain, Yaniv, Briscoe Runquist, Ryan, Ryan Briscoe Runquist (3251181)   +7 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

High Outcrossing Levels among Global Macadamia Cultivars: Implications for Nut Quality, Orchard Designs and Pollinator Management

Horticulturae
Global fruit and nut yields are affected by shortfalls in pollinator populations, and pollen limitation is most prevalent among tropical, bee-pollinated and self-incompatible plants. Macadamia is a subtropical, bee-pollinated crop in which some cultivars
Stephen J. Trueman, Mark G. Penter, Kátia Sampaio Malagodi-Braga, Joel Nichols, Anushika L. De Silva, Adalgisa Thayne Munhoz Ramos, Leonardo Massaharu Moriya, Steven M. Ogbourne, David Hawkes, Trent Peters, Naga Kasinadhuni, Shahla Hosseini Bai, Helen M. Wallace, Wiebke Kämper   +13 more
doaj   +1 more source

Parent-offspring correlations under full-sib and parent-offspring mating systems

, 1975
A study of the parent-offspring correlations under full-sib mating and parent-offspring mating system has been conducted. A general theory for obtaining the correlation between one parent and k offspring, as well as the correlation between both the ...
George, K. C., Narain, P.
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source