Results 121 to 130 of about 17,602,067 (294)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Male Agonistic Behavior on Atlantic Cod Spawning Grounds
Ecology and EvolutionThe mating system of the iconic Atlantic cod (Gadus morhua) has been described as a lek, a mating system where male–male agonistic interactions are expected. However, observing such behaviors directly in marine environments is challenging.
J. E. Skjæraasen +11 more
doaj +1 more source
Frontiers in Plant ScienceThe mating system of non-native plant populations plays a role in determining the colonizing success following introduction into locations outside of the native distribution.
Michele R. Dudash +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Changes in educational assortative mating in contemporary Spain [PDF]
This article analyses patterns and trends in educational assortative mating of the Spanish women born between 1920 and 1969 using data from the 2001 Spanish Census. By means of loglinear models we examine the following issues: i) intensity and changes in
Albert Esteve, Clara Cortina
core
Analysis of mating system in two Pinus cembra L. populations of the Ukrainian Carpathians [PDF]
Annals of Forest Research, 2008 In natural pine populations, a mixed mating system is typical,characterized by the proportions of selfed and outcrossed seeds. Swiss stone pine(Pinus cembra L.) is one of the least studied European conifers in this respect.
Dmitri V. Politov +4 more
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Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular ecology of southern elephant seals (mirounga leonina): mating system and population genetics [PDF]
, 2002 The general aim of this research was the analysis of the mating system and the genetic structure of the southern elephant seal (Mirounga leonina). The specific objectives were to: 1) estimate the distribution of paternity and the relationship between ...
Fabiani, Anna
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, 2018 (A) Donor selection controlled by heterochromatin. In the presence of heterochromatin, mat2-P is preferred over mat3-M in M cells due to an increased accessibility of SRE2 to switch-promoting binding factors and to a reduced accessibility of SRE3. In the
Geneviève Thon (13482) +4 more
core +1 more source
Features of Sexual Reproduction and Mating System of Ulnaria acus (Bacillariophyta) [PDF]
Журнал Сибирского федерального университета: Серия Биология, 2018 Sexual reproduction and mating system of the freshwater diatom Ulnaria acus (Bacillariophyta) was described for the first time. Mating system of the species includes, apparently, only heterothallic way of reproduction: during the three-year observation ...
Yulia A. Podunay +3 more
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