Results 101 to 110 of about 221,203 (298)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Sociogenetic structure in nests of the mud dauber wasp Trypoxylon (Trypargilum) albitarse (Hymenoptera: Crabronidae)

open access: yesEuropean Journal of Entomology, 2015
Trypargilum is a subgenus of solitary spider-hunting wasps whose males guard the nest, an unusual behaviour for male wasps. A male pairs with a female and copulates repeatedly with her during the nesting process, although females regularly copulate with ...
Antonio C. BRAGATO BERGAMASCHI   +3 more
doaj   +1 more source

Sexual selection and mating systems [PDF]

open access: yesProceedings of the National Academy of Sciences, 2009
Sexual selection is among the most powerful of all evolutionary forces. It occurs when individuals within one sex secure mates and produce offspring at the expense of other individuals within the same sex. Darwin was first to recognize the power of sexual selection to change male and female phenotypes, and, in noting that sexual selection is ...
openaire   +2 more sources

Mating-Induced Increase in Germline Stem Cells via the Neuroendocrine System in Female Drosophila.

open access: yes, 2016
Mating and gametogenesis are two essential components of animal reproduction. Gametogenesis must be modulated by the need for gametes, yet little is known of how mating, a process that utilizes gametes, may modulate the process of gametogenesis. Here, we
Ryusuke Niwa (141031)   +3 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Young adults' sexual strategies and mating displays in the virtual world: an evolutionary perspective

open access: yes, 2013
Includes bibliographical references.Life History Theory (LHT) predicts that natural selection favours a degree of developmental plasticity when it comes to sexual strategies and mating displays.
Swanepoel, Tarah
core  

Predator-induced changes of female mating preferences: innate and experiential effects

open access: yes, 2011
Background: In many species males face a higher predation risk than females because males display elaborate traits that evolved under sexual selection, which may attract not only females but also predators. Females are, therefore, predicted to avoid such
Michael Tobler   +39 more
core   +1 more source

Are sex ratio distorting endosymbionts responsible for mating system variation among dance flies (Diptera: Empidinae)? [PDF]

open access: yes, 2017
Maternally inherited bacterial endosymbionts are common in many arthropod species. Some endosymbionts cause female-biased sex ratio distortion in their hosts that can result in profound changes to a host's mating behaviour and reproductive biology. Dance
Ness, Rob W   +11 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

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