Results 111 to 120 of about 221,203 (298)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Outcrossing in Caenorhabditis elegans increases in response to food limitation
Ecology and EvolutionTheory predicts that organisms should diversify their offspring when faced with a stressful environment. This prediction has received empirical support across diverse groups of organisms and stressors.
Samuel P. Slowinski +5 more
doaj +1 more source
Ornamental HorticultureVanilla planifolia Jacks. is an orchid of great economic interest, classified as endangered. The limited genetic variation of this species has been primarily attributed to its clonal propagation.
Zelzin Eréndira Fernández-Villa +2 more
doaj +1 more source
, 2016 Androdioecy was first described by Darwin in his seminal work on barnacle diversity; he identified males and hermaphrodites in the same reproductive population. Today, we realize that many androdioecious plants and animals share astonishing similarities,
Ewers-Saucedo, Christine +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The mating systems of pinnipeds and marine iguanas: convergent evolution of polygyny
, 1984 Trillmich F, Trillmich KGK. The mating systems of pinnipeds and marine iguanas: convergent evolution of polygyny. Biological Journal of the Linnean Society.
Trillmich, Fritz ; https://orcid.org/ +1 more
core
Do the benefits of polyandry scale with outbreeding?
, 2015 There have been many potential explanations put forward as to why polyandry often persists despite the multiple costs it can inflict on females. One such explanation is avoidance of costs associated with mating with genetically incompatible males ...
Burdfield-Steel, Emily Rose +4 more
core +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Male scorpionflies assess the amount of rival sperm transferred by females' previous mates
, 2007 Engqvist L. Male scorpionflies assess the amount of rival sperm transferred by females' previous mates. Evolution. 2007;61(6):1489-1494.Theory predicts that when sperm compete numerically, selection will favor males who vary the number of sperm they ...
Engqvist, Leif ; https://orcid.org/
core +1 more source