Results 91 to 100 of about 7,046,764 (253)

Genotyping of the MTL loci and susceptibility to two antifungal agents of Candida glabrata clinical isolates

Memorias do Instituto Oswaldo Cruz, 2009
The opportunistic fungal pathogen Candida glabrata is the second most common isolate from bloodstream infections worldwide and is naturally less susceptible to the antifungal drug fluconazole than other Candida species. C.
María Teresa Lavaniegos-Sobrino, Candy Y Ramírez-Zavaleta, Alfredo Ponce de León, José Sifuentes-Osornio, Miriam Bobadilla-Del Valle, Andrea Rangel-Cordero, Alejandro De Las Peñas, Irene Castaño   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Mating

, 2016
Data from mating experiments, formatted for jMating ...
Molly S. Hunter (3197472), Hammerstein, Peter, Marco Gebiola (738538), Massimo Giorgini (738541), Gebiola, Marco, Kelly, Suzanne E., Suzanne E. Kelly (124703), Giorgini, Massimo, Peter Hammerstein (221627), Hunter, Molly S.   +9 more
core   +1 more source

Roving females and patient males: a new perspective on the mating strategies of chimpanzees [PDF]

, 2014
Mating strategies are sets of decisions aimed at maximizing reproductive success. For male animals, the fundamental problem that these strategies address is attaining mating access to females in a manner that maximizes their chances of achieving ...
Newton-Fisher, Nicholas E.
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mating

, 2019
Male (son, 2nd generation) mating trial ...
Chin, Eunice, Eunice Chin (6500285), Rampton, Rowan, Tony D Williams (5025851), Torres, Roxana, Williams, Tony D, Roxana Torres (340024), Rowan Rampton (6500288)   +7 more
core   +1 more source

A Molecular Marker System Based on Whole-Genome Sequencing for Mating Type Identification in Major Chinese Cultivars of Lentinula edodes

Horticulturae
Lentinula edodes (shiitake) is a globally significant edible mushroom, with China being its largest producer. Efficient breeding is fundamental to sustaining its industry, yet it is often hindered by the labor-intensive and time-consuming nature of ...
Xiangqian Wang, Linping Li, Yuanyuan Liu, Qi Gao, Yangyang Fan, Gawesha Yasapalaa, Xia Gao, Shouxian Wang, Yu Liu, Dong Yan   +9 more
doaj   +1 more source

The Conformation of Yeast Chromosome III Is Mating Type Dependent and Controlled by the Recombination Enhancer

Cell Reports, 2015
Mating-type switching in yeast occurs through gene conversion between the MAT locus and one of two silent loci (HML or HMR) on opposite ends of the chromosome. MATa cells choose HML as template, whereas MATα cells use HMR. The recombination enhancer (RE)
Jon-Matthew Belton, Bryan R. Lajoie, Sylvain Audibert, Sylvain Cantaloube, Imen Lassadi, Isabelle Goiffon, Davide Baù, Marc A. Marti-Renom, Kerstin Bystricky, Job Dekker   +9 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Mating success and potential male-worker conflict in a male-dimorphic ant [PDF]

, 2007
Background: Males of many species adjust their reproductive tactics with regard to their condition and status. For example, large males may develop weapons and fight for access to females, whereas small or undernourished males do not express costly ...
Darrouzet, Eric, Heinze Jürgen, Schrempf, Alexandra, Heinze, Jürgen, Schrempf Alexandra, Darrouzet Eric   +5 more
core   +1 more source