Results 61 to 70 of about 4,872,302 (299)
Allelic exchange of pheromones and their receptors reprograms sexual identity in Cryptococcus neoformans. [PDF]
PLoS Genetics, 2010 Cell type specification is a fundamental process that all cells must carry out to ensure appropriate behaviors in response to environmental stimuli.
Brynne C Stanton +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Discovery and Characterization of Epichloë Fungal Endophytes from Elymus spp. in Northwest China
MicroorganismsEpichloë fungal endophytes hold promise in sustainable agriculture by fortifying cool-season grasses such as Elymus spp. against various stresses. Elymus spp. are widely distributed in Northwest China with a high incidence of endophyte infections.
Mingxiang Du +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Mating types and sequence types of P. dipodomyis isolates.
, 2013 Mating types and sequence types of P. dipodomyis isolates.
Daniel A. Henk (129712) +1 more
core +1 more source
eLifeThe long-term balancing selection acting on mating types or sex-determining genes is expected to lead to the accumulation of deleterious mutations in the tightly linked chromosomal segments that are locally ‘sheltered’ from purifying selection.
Audrey Le Veve +7 more
doaj +1 more source
Activation of the Mating Pheromone Response Pathway of Lentinula edodes by Synthetic Pheromones
Mycobiology, 2018 Pheromone (PHB)-receptor (RCB) interaction in the mating pheromone response pathway of Lentinula edodes was investigated using synthetic PHBs. Functionality of the C-terminally carboxymethylated synthetic PHBs was demonstrated by concentration-dependent ...
Byeongsuk Ha +3 more
doaj +1 more source
PLoS Genetics, 2023 Recombination is often suppressed at sex-determining loci in plants and animals, and at self-incompatibility or mating-type loci in plants and fungi. In fungal ascomycetes, recombination suppression around the mating-type locus is associated with pseudo ...
Nina Vittorelli +15 more
doaj +1 more source