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Matrine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis and Apoptosis
Inflammation, 2023Yuhong Xiao +7 more
semanticscholar +1 more source
[Anti-arrhythmic effects of matrine].
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991Matrine (MT) is an alkaloid isolated from Sophra alopecuroids L. The LD50 of MT iv to mice was 72.1 mg/kg (95% CL 68.2-76.5 mg/kg). MT had significant effects on different experimental models of arrhythmias induced by aconitine, barium chloride or coronary ligation. The ECG of anesthetized rats was significantly changed after iv of MT.
B H, Zhang +4 more
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[Pharmacokinetics of matrine in healthy volunteers].
Yao xue xue bao = Acta pharmaceutica Sinica, 1994A sensitive high performance liquid chromatographic analytical method was established for determining the concentration of matrine in human serum. The recovery of matrine was 99.1-102.2%. The RSD (%) in within-day and between-days were no more than 6%. The calibration curve was linear in the range from 1.25 micrograms.ml-1 to 40.0 micrograms.ml-1 with ...
P Q, Wang +6 more
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Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways
Metabolic brain disease, 2023Swesha Chhabra, Sidharth Mehan
semanticscholar +1 more source
Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis.
Chemico-Biological Interactions, 2023Xi Wang +5 more
semanticscholar +1 more source