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Matrisome changes in Parkinson’s disease
Analytical and Bioanalytical Chemistry, 2022Extracellular matrix (ECM) proteins, collectively known as the matrisome, include collagens, glycoproteins, and proteoglycans. Alterations in the matrisome have been implicated in the neurodegenerative pathologies including Parkinson's disease (PD). In this work, we utilized our previously published PD and control proteomics data from human prefrontal ...
Margaret Downs +4 more
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NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
Cancer Research, 2022Abstract Sarcomas produce an abnormal extracellular matrix (ECM), which in turn provides instructive cues for cell growth and invasion. Neural EGF like-like molecule 1 (NELL1) is a secreted glycoprotein characterized by its nonneoplastic osteoinductive effects, yet it is highly expressed in ...
Qizhi Qin +8 more
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Integration of Matrisome Omics: Towards System Biology of the Tumor Matrisome
2020The tumor matrisome, the collection of structural and functional extracellular matrix (ECM) proteins found in tumors together with ECM-associated proteins, growth factors, cytokines and chemokines is an extremely dynamic entity whose composition and regulation depends on both local, cell-specific processes and overarching pan-cancer microenvironmental ...
Valerio Izzi +4 more
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Citrullination of matrisomal proteins in health and diseases
Philosophical Transactions of the Royal Society B: Biological Sciences, 2023Proteins once translated are subjected to post-translational modifications (PTMs) that can critically modify their characteristics. Citrullination is a unique type of PTM that is catalysed by peptidylarginine deiminase (PAD) enzymes, which regulate a multitude of physiological functions such as apoptosis, gene expression and immune response by altering
Mohammad Aslam Saifi, I-Cheng Ho
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1991
In the past twelve years it has become clear that most neurotransmitter systems in the striatum are differentially distributed with respect to striosomes (“striatal bodies”) and their surrounding extrastriosomal matrix (Graybiel and Ragsdale, 1978, 1983; Herkenham and Pert, 1981; Gerfen, 1984; Gerfen et al., 1985a).
A. M. Graybiel +2 more
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In the past twelve years it has become clear that most neurotransmitter systems in the striatum are differentially distributed with respect to striosomes (“striatal bodies”) and their surrounding extrastriosomal matrix (Graybiel and Ragsdale, 1978, 1983; Herkenham and Pert, 1981; Gerfen, 1984; Gerfen et al., 1985a).
A. M. Graybiel +2 more
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The “Matrisome” reveals the characterization of skin keloid microenvironment
The FASEB Journal, 2021Abstract Keloids are fibroproliferative dermal tumors of unknown origin that are characterized by the overabundant accumulation of extracellular matrix (ECM) components. The mechanism of keloid formation has remained unclear because of a poor understanding of its molecular basis.
Shikun Zhang +10 more
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A matrisome atlas of germ cell development
2023AbstractThe extracellular matrix (matrisome) provides chemical and mechanical cues to control the structure and function of cells and tissues. Yet, comprehensive understanding of how matrisome factors individually and collectively control cell and tissue behaviorin vivois lacking.
Aqilah Amran +5 more
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The cancer matrisome: From comprehensive characterization to biomarker discovery
Seminars in Cell & Developmental Biology, 2019Tumor progression and dissemination critically depend on support from the tumor microenvironment, the ensemble of cellular and acellular components surrounding and interacting with tumor cells. The extracellular matrix (ECM), the complex scaffolding of hundreds of proteins organizing cells in tissues, is a major component of the tumor microenvironment.
Alexandra M. Socovich, Alexandra Naba
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Functional Bioinformatics Analyses of the Matrisome and Integrin Adhesome
2020The extracellular matrix (ECM) is the noncellular compartment of living organisms and is formed of a complex network of cross-linked proteins, which is collectively known as the matrisome. Apart from providing the structure for an organism, cells interact and thereby communicate with the ECM. Cells interact with their surrounding ECM using cell-surface
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