Results 51 to 60 of about 285,460 (269)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Quantum Conjugacy Classes of Simple Matrix Groups [PDF]

Communications in Mathematical Physics, 2007
Let $G$ be a simple complex classical group and $\g$ its Lie algebra. Let $\U_\hbar(\g)$ be the Drinfeld-Jimbo quantization of the universal enveloping algebra $\U(\g)$. We construct an explicit $\U_\hbar(\g)$-equivariant quantization of conjugacy classes of $G$ with Levi subgroups as the stabilizers.
openaire   +4 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Spectral properties for polynomial and matrix operators involving demicompactness classes

Extracta Mathematicae, 2018
The first aim of this paper is to show that a polynomially demicompact operator satisfying certain conditions is demicompact. Furthermore, we give a refinement of the Schmoëger and the Rakocević essential spectra of a closed linear operator involving ...
Fatma Ben Brahim, Aref Jeribi, Bilel Krichen   +2 more
doaj  

Sloppy-Model Universality Class and the Vandermonde Matrix [PDF]

Physical Review Letters, 2006
In a variety of contexts, physicists study complex, nonlinear models with many unknown or tunable parameters to explain experimental data. We explain why such systems so often are sloppy; the system behavior depends only on a few `stiff' combinations of the parameters and is unchanged as other `sloppy' parameter combinations vary by orders of magnitude.
Waterfall, Joshua J., Casey, Fergal P., Gutenkunst, Ryan N., Brown, Kevin S., Myers, Christopher R., Brouwer, Piet W., Elser, Veit, Sethna, James P.   +7 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Loucura e razão: produzindo classes interativas

Arquivos Brasileiros de Psicologia, 2014
The article proposes a discussion of some present configurations of madness, reviewing, in the first moment, the ideas of Ian Hacking, in order to think this existence mode as an operative effect of a matrix that constitutes social interactive ...
Andrea Cristina Scisleski, Cleci Maraschin   +1 more
doaj  

Robust Learning of Mislabeled Training Samples for Remote Sensing Image Scene Classification

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2020
Label information plays an important role in supervised high-resolution remote sensing (HRRS) image scene classification. However, the labels of a dataset are probably unreliable and may contain “noisy” labels.
Bing Tu, Wenlan Kuang, Wangquan He, Guoyun Zhang, Yishu Peng   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source