Results 61 to 70 of about 310,012 (309)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Spectral properties for polynomial and matrix operators involving demicompactness classes

Extracta Mathematicae, 2018
The first aim of this paper is to show that a polynomially demicompact operator satisfying certain conditions is demicompact. Furthermore, we give a refinement of the Schmoëger and the Rakocević essential spectra of a closed linear operator involving ...
Fatma Ben Brahim, Aref Jeribi, Bilel Krichen   +2 more
doaj  

Material classes and conductivities used to calculate the lead field matrix.

, 2022
Material classes and conductivities used to calculate the lead field matrix.
Tibor Hornyik (3342668), Gunnar Seemann (500667), Katja E. Odening (8122919), Stefanie Perez-Feliz (12981821), Axel Krafft (12981827), Marius Menza (4579693), Robin Moss (5843066), Tim Strohbach (12981824), Raphaela Lewetag (12981818), Eike M. Wülfers (10860777)   +9 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Language classes associated with automata over matrix groups [PDF]

, 2018
We investigate the language classes recognized by group automata over matrix groups. We present a summary of the results obtained so far together with a number of new results. We look at the computational power of time-bounded group automata where the
Özlem Salehi, A.C. Cem Say, Say, A. C. Cem, Say, Cem, Salehi, Ozlem, Say, A.C. Cem, Özlem, Salehi, Flavio D’Alessandro, Cem Say, A. C., D’Alessandro, Flavio, D'ALESSANDRO, Flavio   +10 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Loucura e razão: produzindo classes interativas

Arquivos Brasileiros de Psicologia, 2014
The article proposes a discussion of some present configurations of madness, reviewing, in the first moment, the ideas of Ian Hacking, in order to think this existence mode as an operative effect of a matrix that constitutes social interactive ...
Andrea Cristina Scisleski, Cleci Maraschin   +1 more
doaj  

Ridge estimation of covariance matrix from data in two classes

summary:This paper deals with the problem of estimating a covariance matrix from the data in two classes: (1) good data with the covariance matrix of interest and (2) contamination coming from a Gaussian distribution with a different covariance matrix ...
Zhou, Yi, Zhang, Bin
core   +1 more source

Change matrix for erosion risk classes from 1990 to 2010 (%).

, 2016
Change matrix for erosion risk classes from 1990 to 2010 (%).
Kabir Uddin (3214380), M. S. R. Murthy (3214383), Mir A. Matin (3187044), Shahriar M. Wahid (3214386)   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source