Results 61 to 70 of about 285,460 (269)
Ingeniería e Investigación, 2010 La planeación estratégica de sistemas de información (PESI) es el proceso por medio del cual una organización determina el portafolio de aplicaciones de computador para ayudar a lograr sus objetivos de negocios.
Javier Andrés Arias Sanabria +2 more
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
New classes of matrix decompositions
Linear Algebra and its Applications, 2017 The idea of decomposing a matrix into a product of structured matrices such as triangular, orthogonal, diagonal matrices is a milestone of numerical computations. In this paper, we describe six new classes of matrix decompositions, extending our work in arXiv:1307.5132.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Challenges in Matrix Metalloproteinases Inhibition
Biomolecules, 2020 Matrix metalloproteinases are enzymes that degrade the extracellular matrix. They have different substrates but similar structural organization. Matrix metalloproteinases are involved in many physiological and pathological processes and there is a need ...
Helena Laronha +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Ecosystems and People, 2019 Recent scientific developments are advancing to link land use and land cover (LULC) change with ecosystem service (ES) potentials. Such links within peri-urban ecosystems are scanty due to methodological and expertise challenge, and data limitation.
Peter Waweru Wangai +2 more
doaj +1 more source
Martingale matrix classes and polytopes
Linear Algebra and its Applications, 2012 Let \(( \Omega, {\mathcal F}, P)\) be a probability space. This paper focuses on discrete time martingales where the underlying sample space is finite. Suppose \(\Omega= \{ \omega_1, \dots, \omega_s \}\) consists of \(s\) elements and \((M_t)_{t \in T}, T=\{1,2, \dots, n\}\) is a martingale, then construct an \(s \times n\) martingale matrix \(M=[ m_ ...
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