Results 71 to 80 of about 118,710 (298)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Direct Matrix Converter Topologies with Model Predictive Current Control Applied as Power Interfaces in AC, DC, and Hybrid Microgrids in Islanded and Grid-Connected Modes

Energies, 2019
This paper presents an analysis of a new application of different direct matrix converter topologies used as power interfaces in AC, DC, and hybrid microgrids, with model predictive current control.
Gustavo Gontijo, Matheus Soares, Thiago Tricarico, Robson Dias, Mauricio Aredes, Josep Guerrero   +5 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dynamic inverse controller with Matrix Converter Drive Feed Three Phase Induction Motor

MATEC Web of Conferences, 2018
Dynamic inversion (DI) is a controller technique by which existing undesirable dynamics are cancelled out and changed by desirable dynamics. The application of induction motor drives with sinusoidal input currents a matrix converter combined with DI is ...
Keream Settar S, Abdalla Ahmed N, Daud Mohd Razali Bin, Koh Johnny   +3 more
doaj   +1 more source

Global Tracking Passivity--based PI Control of Bilinear Systems and its Application to the Boost and Modular Multilevel Converters

, 2015
This paper deals with the problem of trajectory tracking of a class of bilinear systems with time--varying measurable disturbance. A set of matrices {A,B_i} has been identified, via a linear matrix inequality, for which it is possible to ensure global ...
Bergna, G., Cisneros, R., Ippoliti, G., Molinas, M., Ortega, R., Pirro, M.   +5 more
core   +4 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Digital-voltage curve generator [PDF]

, 1970
Curve generator capable of producing precisely repeatable curve for any single-valued function of voltage versus time uses digital approach, implemented by means of clocked feedback shift register, large scale integrated circuit diode matrix comprising ...
Perlman, M.
core   +1 more source

Control of matrix converters

, 2007
The book is the result of an intense theoretical and experimental activity on matrix converters carried out at the Department of Electrical Engineering of the University of Bologna. The matrix converter is a direct ac/ac power converter. It has several advantages over the traditional power converters, such as compactness, bidirectional power flow, and ...
openaire   +3 more sources