Results 41 to 50 of about 150,932 (264)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Highly efficient parallel direct solver for solving dense complex matrix equations from method of moments

open access: yesThe Journal of Engineering, 2017
Based on the vectorised and cache optimised kernel, a parallel lower upper decomposition with a novel communication avoiding pivoting scheme is developed to solve dense complex matrix equations generated by the method of moments.
Yan Chen   +4 more
doaj   +1 more source

Guided Semi-Supervised Non-Negative Matrix Factorization

open access: yesAlgorithms, 2022
Classification and topic modeling are popular techniques in machine learning that extract information from large-scale datasets. By incorporating a priori information such as labels or important features, methods have been developed to perform ...
Pengyu Li   +6 more
doaj   +1 more source

Bayesian Matrix Decomposition and Applications

open access: yesCoRR, 2023
The sole aim of this book is to give a self-contained introduction to concepts and mathematical tools in Bayesian matrix decomposition in order to seamlessly introduce matrix decomposition techniques and their applications in subsequent sections. However, we clearly realize our inability to cover all the useful and interesting results concerning ...
openaire   +2 more sources

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi   +8 more
wiley   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif   +17 more
wiley   +1 more source

A System of Four Generalized Sylvester Matrix Equations over the Quaternion Algebra

open access: yesMathematics
In this paper, we make use of the simultaneous decomposition of eight quaternion matrices to study the solvability conditions and general solutions to a system of two-sided coupled Sylvester-type quaternion matrix equations AiXiCi+BiXi+1Di=Ωi,i=1,2,3,4 ...
Zhuo-Heng He, Jie Tian, Shao-Wen Yu
doaj   +1 more source

Fast matrix decomposition in F2

open access: yesCoRR, 2012
20 pages, 4 figure, 6 tables, 1 ...
Bertolazzi, Enrico, Rimoldi, Anna
openaire   +2 more sources

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias   +3 more
wiley   +1 more source

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