Results 81 to 90 of about 1,983,602 (251)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Nonnegative factorization and the maximum edge biclique problem [PDF]
Nonnegative matrix factorization (NMF) is a data analysis technique based on the approximation of a nonnegative matrix with a product of two nonnegative factors, which allows compression and interpretation of nonnegative data. In this paper, we study the
GILLIS, Nicolas, GLINEUR, François
core
Online Kernel Matrix Factorization [PDF]
, 2015 . The problem of effciently applying a kernel-induced feature space factorization to a large-scale data sets is addressed in this thesis. Kernel matrix factorization methods have showed good performances solving machine learning and data analysis ...
Páez Torres, Andrés Esteban
core
Recommender Systems Clustering Using Bayesian Non Negative Matrix Factorization
IEEE Access, 2018 Recommender Systems present a high-level of sparsity in their ratings matrices. The collaborative filtering sparse data makes it difficult to: 1) compare elements using memory-based solutions; 2) obtain precise models using model-based solutions; 3) get ...
Jesus Bobadilla +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Modifying a Sparse Cholesky Factorization
, 1999 Given a sparse symmetric positive de nite matrix AA and an associated sparse Cholesky factorization LDL , we develop sparse techniques for obtaining the new factorization associated with either adding a column to A or deleting a column from A ...
Cholesky Factorization Ldl +3 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Computation of General Inner-Outer and Spectral Factorizations [PDF]
, 2000 In this paper, we solve two problems in linear systems theory: the computation of the inner-outer and spectral factorizations of a continuous-time system considered in the most general setting.
Varga, A., Oara, C.
core
Non-negative matrix factorization.
, 2013 Non-negative matrix factorization.
Daniel Kaliski (336793) +9 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source