Results 71 to 80 of about 1,983,602 (251)
BMC Bioinformatics, 2020 Background Bayesian factorization methods, including Coordinated Gene Activity in Pattern Sets (CoGAPS), are emerging as powerful analysis tools for single cell data.
Thomas D. Sherman +2 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Factorization-based versus alignment-based methods.
, 2020 (A) Factorization-based single-view learning methods. They typically factorize a data matrix X from single view (e.g., gene expression matrix of samples by genes) into a product of matrix G (coefficient matrix) and matrix (dictionary matrix or pattern ...
Nam D. Nguyen (8661216) +1 more
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Big Data Mining and AnalyticsNonnegative Matrix Factorization (NMF) is one of the most popular feature learning technologies in the field of machine learning and pattern recognition. It has been widely used and studied in the multi-view clustering tasks because of its effectiveness.
Guosheng Cui +3 more
doaj +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
A Constrained Sparse Algorithm for Nonnegative Matrix Factorization
工程科学与技术, 2015 :Aiming at the lack of sparseness of factorization matrix in the nonnegative matrix factorization (NMF) algorithm,a new constrained NMF algorithm was proposed.A sparseness constraint was added to the original nonnegative matrix factorization (NMF ...
李臣明, 张师明, 李昌利
doaj
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Evaluating Matrix Factorization Techniques for Thematic Mapping of Wilderness Walkability Using Multiple GPX Datasets [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information SciencesQuantitative thematic mapping of walkability in wilderness areas is challenging due to sparse and unreliable data. Unlike urban walkability, which depends on built infrastructure, wilderness walkability is influenced by natural terrain features such as ...
L. Šerić, B. Draško, A. Ivanda
doaj +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source