Results 51 to 60 of about 1,983,602 (251)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Development of a Real Time Sparse Non-Negative Matrix Factorization Module for Cochlear Implants by Using xPC Target

, 2013
Cochlear implants (CIs) require efficient speech processing to maximize information transmission to the brain, especially in noise. A novel CI processing strategy was proposed in our previous studies, in which sparsity-constrained non-negative matrix ...
Mark Lutman, Bleeck, S., Hu, Hongmei, Lutman, M.E., Agamemnon Krasoulis, Krasoulis, A., Hongmei Hu, Stefan Bleeck   +7 more
core   +1 more source

Followee Recommendation in Microblog Using Matrix Factorization Model with Structural Regularization

The Scientific World Journal, 2014
Microblog that provides us a new communication and information sharing platform has been growing exponentially since it emerged just a few years ago.
Yan Yu, Robin G. Qiu
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Solution to the General Inner-Outer and Spectral Factorization Problems [PDF]

, 1998
In this paper we solve two open problems in linear system theory: the computation of the spectral and inner-outer factorizations of a rational matrix G in the most general setting.
Varga, A., Oara, C.
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Attributes coupling based matrix factorization for item recommendation

, 2017
Recommender systems have attracted lots of attention since they alleviate the information overload problem for users. Matrix factorization is one of the most widely employed collaborative filtering techniques in the research of recommender systems due to
Yang Gao, Wang, Can, Yonghong Yu, Gao, Yang, Hao Wang, Yu, Yonghong, Can Wang, Wang, Hao   +7 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Vector-exponential time-series modeling for polynomial J-spectral factorization

, 2005
An iterative algorithm to perform the J-spectral factorization of a para-Hermitian matrix is presented. The algorithm proceeds by computing a special kernel representation of an interpolant for a sequence of points and associated directions determined ...
Pendharkar, Ishan, Pillai, Harish K., Rapisarda, Paolo   +2 more
core   +1 more source