Results 61 to 70 of about 24,084 (265)

Sparse data embedding and prediction by tropical matrix factorization

open access: yesBMC Bioinformatics, 2021
Background Matrix factorization methods are linear models, with limited capability to model complex relations. In our work, we use tropical semiring to introduce non-linearity into matrix factorization models.
Amra Omanović   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

The factors of a design matrix

open access: yesJournal of Combinatorial Theory, Series A, 1977
AbstractLet X and Y be integral matrices of order n > 1 and suppose that these matrices satisfy the matrix equation XY = B, where B is a matrix with k in the n main diagonal positions and λ and μ in all other positions. Suppose further that k, λ, and μ are nonnegative integers and that λ occurs exactly the same number of times in each line of B and ...
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

A nonsymmetrical matrix and its factorizations

open access: yesMathematica Slovaca, 2019
Abstract We introduce a nonsymmetric matrix defined by q-integers. Explicit formulæ are derived for its LU-decomposition, the inverse matrices L −1 and U −1 and its inverse. Nonsymmetric variants of the Filbert and Lilbert matrices come out as consequences of our results for special choices of q and ...
Arikan, Talha   +2 more
openaire   +3 more sources

Adaptive Kernel Graph Nonnegative Matrix Factorization

open access: yesInformation, 2023
Nonnegative matrix factorization (NMF) is an efficient method for feature learning in the field of machine learning and data mining. To investigate the nonlinear characteristics of datasets, kernel-method-based NMF (KNMF) and its graph-regularized ...
Rui-Yu Li, Yu Guo, Bin Zhang
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Matrix factorization with Binary Components

open access: yesCoRR, 2014
appeared in NIPS ...
Martin Slawski   +2 more
openaire   +3 more sources

Evolving Matrix-Factorization-Based Collaborative Filtering Using Genetic Programming

open access: yesApplied Sciences, 2020
Recommender systems aim to estimate the judgment or opinion that a user might offer to an item. Matrix-factorization-based collaborative filtering typifies both users and items as vectors of factors inferred from item rating patterns.
Raúl Lara-Cabrera   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

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