Results 61 to 70 of about 1,630,238 (295)
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Tensor Factorization via Matrix Factorization
Tensor factorization arises in many machine learning applications, such knowledge base modeling and parameter estimation in latent variable models. However, numerical methods for tensor factorization have not reached the level of maturity of matrix factorization methods.
Volodymyr Kuleshov +2 more
openaire +3 more sources
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Nonsquare Spectral Factorization for Nonlinear Control Systems [PDF]
This paper considers nonsquare spectral factorization of nonlinear input affine state space systems in continuous time. More specifically, we obtain a parametrization of nonsquare spectral factors in terms of invariant Lagrangian submanifolds and ...
Schaft, Arjan J. van der +4 more
core +2 more sources
Network Embedding Using Deep Robust Nonnegative Matrix Factorization
As an effective technique to learn low-dimensional node features in complicated network environment, network embedding has become a promising research direction in the field of network analysis.
Chaobo He +5 more
doaj +1 more source
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Quantized nonnegative matrix factorization [PDF]
Even though Nonnegative Matrix Factorization (NMF) in its original form performs rank reduction and signal compaction implicitly, it does not explicitly consider storage or transmission constraints. We propose a Frobenius-norm Quantized Nonnegative Matrix Factorization algorithm that is 1) almost as precise as traditional NMF for decomposition ranks of
openaire +4 more sources
The General Inner-Outer Factorization Problem for Discrete-Time Systems [PDF]
In this paper we give a theoretical and a computational solution to the most general inner-outer factorization problem formulated for a discrete-time system G.
A. Varga +3 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source

