Results 91 to 100 of about 4,454,720 (286)

Soft matrix models and Chern-Simons partition functions

, 2004
We study the properties of matrix models with soft confining potentials. Their precise mathematical characterization is that their weight function is not determined by its moments.
't Hooft G., M. TIERZ, Mehta M. L., Muttalib K. A., Szego G., Wigert S.   +5 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations

Nature Communications
Collagen VI links the cell surface to the extracellular matrix to provide mechanical strength to most mammalian tissues, and is linked to human diseases including muscular dystrophy, fibrosis, cardiovascular disease and osteoarthritis.
Alan R. F. Godwin, Mark H. Becker, Rana Dajani, Matthew Snee, Alan M. Roseman, Clair Baldock   +5 more
doaj   +1 more source

Exact Expressions for Kullback–Leibler Divergence for Multivariate and Matrix-Variate Distributions

Entropy
The Kullback–Leibler divergence is a measure of the divergence between two probability distributions, often used in statistics and information theory. However, exact expressions for it are not known for multivariate or matrix-variate distributions apart ...
Victor Nawa, Saralees Nadarajah
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Bivariate matrix functions [PDF]

Operators and Matrices, 2014
A definition of bivariate matrix functions is introduced and some theoretical as well as algorithmic aspects are analyzed. It is shown that our framework naturally extends the usual notion of (univariate) matrix functions and allows to unify existing results on linear matrix equations and derivatives of matrix functions.
openaire   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Vector-Valued Polynomials and a Matrix Weight Function with B2-Action. II

Symmetry, Integrability and Geometry: Methods and Applications, 2013
This is a sequel to [SIGMA 9 (2013), 007, 23 pages], in which there is a construction of a 2×2 positive-definite matrix function K(x) on R^2. The entries of K(x) are expressed in terms of hypergeometric functions. This matrix is used in the formula for a
Charles F. Dunkl
doaj   +1 more source

Development and Characterisation of an in vitro Model of Wallerian Degeneration

Frontiers in Bioengineering and Biotechnology, 2020
Following peripheral nerve injury, a sequence of events termed Wallerian degeneration (WD) takes place at the distal stump in order to allow the regenerating axons to grow back toward the target organs.
Heba Elsayed, Heba Elsayed, Alessandro Faroni, Mohammad R. Ashraf, Judith Osuji, Lydia Wunderley, Ling Zhang, Hesham Elsobky, Mohamed Mansour, Ashraf S. Zidan, Ashraf S. Zidan, Adam J. Reid, Adam J. Reid   +12 more
doaj   +1 more source