Results 101 to 110 of about 4,068,886 (304)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Observer-based controller design for a vibration isolation stage having hybrid electromagnets
Journal of Low Frequency Noise, Vibration and Active Control, 2018 Vibration isolation systems based on hybrid electromagnets, consisting of electromagnet and permanent magnet, have a potential usage in many industrial areas, such as clean room design, transportation, semiconductor manufacturing, suspension systems, and
Barış Can Yalçın +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Journal of Marine Science and EngineeringThe Stewart-platform-based bumper plays a critical role in shipborne strap-down inertial navigation systems (SINSs), effectively mitigating shock-induced disturbances to ensure measurement accuracy.
Yongqiang Tu +8 more
doaj +1 more source
CHIMIA, 2005 Three examples from the work of the author's research group on reactive intermediates are used to illustrate how fruitful interaction between experimental and computational chemistry may lead to the solution of problems that neither of the two ...
Thomas Bally
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Trehalose-enhanced isolation of neuronal sub-types from adult mouse brain
BioTechniques, 2012 Efficient isolation of specific, intact, living neurons from the adult brain is problematic due to the complex nature of the extracellular matrix consolidating the neuronal network.
Alka Saxena +9 more
doaj +1 more source
Impeded Growth of Magnetic Flux Bubbles in the Intermediate State Pattern of Type I Superconductors
, 2005 Normal state bubble patterns in Type I superconducting Indium and Lead slabs are studied by the high resolution magneto-optical imaging technique. The size of bubbles is found to be almost independent of the long-range interaction between the normal ...
A. Hubert +12 more
core +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
RNA extraction from sorted neuronal subtypes
BioTechniques, 2017 Protocol Summary Efficient isolation of specific, intact, living neurons from the adult brain is problematic due to the complex nature of the extracellular matrix consolidating the neuronal network.
Alka Saxena +9 more
doaj +1 more source