Results 61 to 70 of about 2,686,420 (304)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Analysis of the proteinaceous components of the organic matrix of calcitic sclerites from the soft coral Sinularia sp. [PDF]
, 2013 An organic matrix consisting of a protein-polysaccharide complex is generally accepted as an important medium for the calcification process. While the role this "calcified organic matrix" plays in the calcification process has long been appreciated, the ...
Ryuichi Shinjo (187750) +11 more
core +2 more sources
Molecular dynamics view on matrix isolation
, 2022 Ability to identify different molecules is one of key goals in chemistry. A common modern way is to identify molecules based on their vibrations that can be detected by infrared spectroscopy or vibrational Raman spectroscopy.
Järvinen, Teemu
core +1 more source
, 2014 Citation: 'matrix isolation' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.M03760 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Fault detection and isolation of actuator failures for a large transport aircraft [PDF]
, 2007 - We consider the problem of designing residual generators with least dynamical orders to solve actuator fault detection and isolation problems for a Boeing 747-100/200 aircraft. The main result of our analysis is the proof of feasibility of the complete
Varga, Andreas
core
A study of the variability in the molecular structure of the human pancreas with age and its effect on islet isolation and transplantation outcomes: Impact of donor age on the structure and enzymatic digestion of the pancreatic extrecellular matrix during human islet isolation [PDF]
, 2020 Pancreatic islet transplantation is a minimally invasive treatment that has the potential to reverse Type 1 Diabetes Mellitus in selected patients. Islets of Langerhans are isolated (extracted) from the pancreatic exocrine tissue using a collagenase and ...
Spiers, Rebecca
core +1 more source
Phage matrix for isolation of glioma cell membrane proteins
BioTechniques, 2004 Cell-binding ligands for RG2 rat glioma were identified in our recent study from a library of peptides that are displayed as fusion molecules on phage particles.
Tatiana I. Samoylova +6 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source