Results 81 to 90 of about 4,068,886 (304)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
, 2014 Citation: 'matrix isolation' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.M03760 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
, 2018 The amount and arrangement of habitat is a fundamental determinant of biodiversity and ecosystem processes in a landscape. Biodiversity is expected to decline following habitat loss and isolation, potentially impeding ecosystem function.
Brian J Spiesman +2 more
semanticscholar +1 more source
A thermoresponsive and magnetic colloid for 3D cell expansion and reconfiguration [PDF]
, 2015 A dual thermoresponsive and magnetic colloidal gel matrix is described for enhanced stem-cell culture. The combined properties of the material allow enzyme-free passaging and expansion of mesenchymal stem cells, as well as isolation of cells postculture ...
Alexander, Cameron +11 more
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Matrix isolation as a tool for studying interstellar chemical reactions [PDF]
Since the identification of the OH radical as an interstellar species, over 50 molecular species were identified as interstellar denizens. While identification of new species appears straightforward, an explanation for their mechanisms of formation is ...
Ball, David W. +3 more
core +1 more source
ORGANIC FARMS AS REFUGES FOR SMALL MAMMAL BIODIVERSITY [PDF]
, 2009 Habitat fragmentation, the process by which relatively continuous habitats is broken into smaller pieces, occurs in natural systems but is to a high degree also human- induced through landscape use.
Hansen, Tine Sussi +2 more
core
, 2014 Patterns of isolation-by-distance arise when population differentiation increases with increasing geographic distances. Patterns of isolation-by-distance are usually caused by local spatial dispersal, which explains why differences of allele frequencies ...
Blum, Michael G. B. +1 more
core +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Matrix isolation study of the reaction of f atoms with co infrared and ultraviolet spectrum of the free radical fco [PDF]
Matrix isolation of reaction of fluorine atoms with carbon monoxide - infrared and ultraviolet spectrum of free radical fluorocarbon ...
Bass, A. M. +4 more
core +1 more source