Matrix metallopeptidases regulate granulosa cell remodeling through the hormone signaling pathway [PDF]
Journal of Advanced Veterinary and Animal Research, 2020 Objective: Granulosa cells (GCs) play a very important role in reproductive physiology due to their effect on developmental and functional changes. However, there are differing views regard¬ing the mechanism by which hormones stimulate GCs.
Sang Hwan Kim, Jong Taek Yoon
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Low-intensity pulsed ultrasound affects proliferation and migration of human hepatocellular carcinoma cells [PDF]
Journal of Cancer Research and Clinical OncologyPurpose Low-intensity pulsed ultrasound (LIPUS) is an effective ancillary treatment modality for various malignancies. However, the mechanisms underlying the role of LIPUS in cancer treatment have not been fully elucidated.
Mingzhen Yang +5 more
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Prostaglandins effect on matrix metallopeptidases and collagen in mare endometrial fibroblasts
Theriogenology, 2020 An increasing number of studies have shown that prostaglandins (PGs) exert multiple regulatory actions in the processes associated to tissue remodeling and fibrosis. Extracellular matrix (ECM) turnover is mediated by matrix metallopeptidases (MMPs). The knowledge about the regulation of their expression in mare endometrium is still limited.
Dariusz Jan Skarzynski +2 more
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Investigating and Annotating the Human Peptidome Profile from Urine under Normal Physiological Conditions [PDF]
ProteomesExamining the composition of the typical urinary peptidome and identifying the enzymes responsible for its formation holds significant importance, as it mirrors the normal physiological state of the human body.
Amr Elguoshy +5 more
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Peripheral Blood Expression of MMPs and DNA Methylation-Related Genes in Women with Recurrent Spontaneous Abortion: A Case-Control Study [version 2; peer review: 2 approved] [PDF]
F1000ResearchBackground Recurrent spontaneous abortion (RSA) is one of the most common reproductive complications among women of childbearing age. Several factors—including genetic, anatomical, endocrine, infectious, environmental, and immunological causes—have been ...
Fateme Zare +4 more
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Matrix Metallopeptidase 9 Promotes Contraction in Human Uterine Myometrium. [PDF]
Reprod SciAbstract Matrix metallopeptidase 9 (MMP9) is a secreted zinc-dependent peptidase known for extracellular remodeling. MMP9 is elevated in tissues from women experiencing preterm labor, and previous research has shown that the addition of combined matrix metallopeptidases 2 and 9 (MMP2/9) enhances uterine contractions.
Ulrich CC +7 more
europepmc +3 more sources
Association of the MMP-3, MMP-9 and MMP-12 gene polymorphisms with COPD risk: a meta-analysis
Archives of Medical Science, 2021 Introduction Given the evidence that the matrix metalloproteinases (MMPs) play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD), a number of case-control studies have attempted to assess the relationship between ...
Hua Zhao +4 more
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Association of Sonic Hedgehog with the extracellular matrix requires its zinc-coordination center
BMC Molecular and Cell Biology, 2021 Background Sonic Hedgehog (Shh) has a catalytic cleft characteristic for zinc metallopeptidases and has significant sequence similarities with some bacterial peptidoglycan metallopeptidases defining a subgroup within the M15A family that, besides having ...
Carina Jägers, Henk Roelink
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e causes cellular trans-differentiation in human bronchial epithelia
Innate Immunity, 2021 Non-typeable Haemophilus influenzae (NTHi) is the most common respiratory pathogen in patients with chronic obstructive disease. Limited data is available investigating the impact of NTHi infections on cellular re-differentiation processes in the ...
Michael Glöckner +8 more
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Characterization of Ca2+ interactions with matrix metallopeptidase-12: implications for matrix metallopeptidase regulation [PDF]
Biochemical Journal, 2006 Matrix metallopeptidase-12 (MMP-12) binds three calcium ions and a zinc ion, in addition to the catalytic zinc ion. These ions are thought to have a structural role, stabilizing the active conformation of the enzyme. To characterize the importance of Ca2+ binding for MMP-12 activity and the properties of the different Ca2+ sites, the activity as a ...
Thomas, Gossas, U Helena, Danielson
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