Results 71 to 80 of about 1,579,901 (232)

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Evolution of Blood-Brain Barrier Permeability in Subacute Ischemic Stroke and Associations With Serum Biomarkers and Functional Outcome

Frontiers in Neurology, 2021
Background and Purpose: In the setting of acute ischemic stroke, increased blood-brain barrier permeability (BBBP) as a sign of injury is believed to be associated with increased risk of poor outcome.
Sarah Müller, Anna Kufner, Anna Kufner, Anna Kufner, Andrea Dell'Orco, Torsten Rackoll, Torsten Rackoll, Torsten Rackoll, Ralf Mekle, Sophie K. Piper, Sophie K. Piper, Jochen B. Fiebach, Kersten Villringer, Agnes Flöel, Agnes Flöel, Matthias Endres, Matthias Endres, Matthias Endres, Matthias Endres, Matthias Endres, Matthias Endres, Martin Ebinger, Martin Ebinger, Alexander H. Nave, Alexander H. Nave, Alexander H. Nave, Alexander H. Nave   +26 more
doaj   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

The TRAPs From Microglial Vesicles Protect Against Listeria Infection in the CNS

Frontiers in Cellular Neuroscience, 2019
Previous studies have demonstrated that T cells and microglia could fight against cerebral Listeria monocytogenes (Listeria); however, their synergistic anti-Listeria mechanisms remain unknown.
Chao Wang, Yang Wang, Xiaochen Shi, Xudong Tang, Wei Cheng, Xueyan Wang, Yanan An, Shulin Li, Hongyue Xu, Yan Li, Wenjing Luan, Xuefei Wang, Zhaobin Chen, Zhaobin Chen, Mingyuan Liu, Mingyuan Liu, Lu Yu   +16 more
doaj   +1 more source

A Review: Matrix Metallopeptidase-9 Nanoparticles Targeted for the Treatment of Diabetic Foot Ulcers

Journal of Multidisciplinary Healthcare, 2021
Diabetes foot ulcers are a leading cause of death in diabetic individuals. There are very few medicines and treatments that have received regulatory clearance for this indication, and numerous compounds from various pharmacological classes are now in various stages of clinical studies for diabetic foot ulcers treatment. Multiple risk factors contribute
Wakuma Wakene Jifar, Seyfe Asrade Atnafie, Sundaramoorthy Angalaparameswari   +2 more
openaire   +4 more sources

Spatiotemporal Regulation of Hierarchical Assembly of Hydroxyapatite for Enamel Remineralization

Advanced Science, EarlyView.
Biomimetic repair exhibits unique advantages for enamel regeneration compared with conventional clinical treatments. An enzymatic mineralization system (EMS) is developed, where the resulting HAP nanorods hierarchically assemble into a highly ordered structure on the enamel surface through the spatiotemporal modulation of interfacial energies of ...
Zhenhang Tang, Zhisen Zhang, Yuanyu Zhou, Wenzhi Wu, Congrui Zhao, Chang Liu, Tong Shi, Wenjing Jin, Zhaoming Liu, Weifeng Fang, Qingyun Lin, Yi He, Zhijian Xie, Ruikang Tang, Changyu Shao, Zhuo Chen   +15 more
wiley   +1 more source

Computational Insights into Mechanisms and Structures of Metallopeptidases and Amyloid Beta Peptide Aggregation

, 2012
In the present thesis, the structural and mechanistic information of natural and artificial metallopeptidases and aggregation mechanisms of amyloid beta (Aβ) peptide associated with Alzheimer’s disease (AD) have been explored using innovative ...
Zhu, Xiaoxia
core   +3 more sources

Crocin's role in modulating MMP2/TIMP1 and mitigating hypoxia-induced pulmonary hypertension in mice

Scientific Reports
To explore the molecular pathogenesis of pulmonary arterial hypertension (PAH) and identify potential therapeutic targets, we performed transcriptome sequencing of lung tissue from mice with hypoxia-induced pulmonary hypertension.
Jing Deng, Rui-Qi Wei, Wen-Mei Zhang, Chang-Yu Shi, Rui Yang, Ming Jin, Chunmei Piao   +6 more
doaj   +1 more source

Detection of matrix metallopeptidase-9-like proteins in Trypanosoma cruzi

Experimental Parasitology, 2010
In this study, the cell-associated and extracellular peptidases of Trypanosoma cruzi grown in modified Roitman's complex (MRC) medium were analyzed by measuring peptidase activity in gelatin-containing zymograms. Our results showed that the cell-associated peptidases as well as peptidases extracellularly released by T.
Ana Cristina, Nogueira de Melo, Edilma Paraguai, de Souza, Camila Guarany Ramalho, Elias, André Luis Souza, dos Santos, Marta Helena, Branquinha, Cláudia Masini, d'Avila-Levy, Flávia Coelho Garcia, dos Reis, Tatiana Ferreira Rocha, Costa, Ana Paula Cabral de Araujo, Lima, Mirian Cláudia, de Souza Pereira, Maria Nazareth Leal, Meirelles, Alane Beatriz, Vermelho   +11 more
openaire   +2 more sources

Twist1 in Infiltrating Macrophages Attenuates Kidney Fibrosis via Matrix Metallopeptidase 13–Mediated Matrix Degradation [PDF]

Journal of the American Society of Nephrology, 2019
Significance Statement Studies have shown profibrotic actions of the transcription factor Twist1 in intrinsic renal parenchymal cells. However, Twist1 expressed by immune cells can suppress inflammatory responses, and the role of macrophage-expressed Twist1 in kidney fibrosis has not been described.
Jiafa, Ren, Jiandong, Zhang, Nathan P, Rudemiller, Robert, Griffiths, Yi, Wen, Xiaohan, Lu, Jamie R, Privratsky, Michael D, Gunn, Steven D, Crowley   +8 more
openaire   +2 more sources