Results 81 to 90 of about 1,579,901 (232)

Serum amyloid A and pairing formyl peptide receptor 2 are expressed in corneas and involved in inflammation-mediated neovascularization [PDF]

International Journal of Ophthalmology, 2014
AIM:To solidify the involvement of Saa-related pathway in corneal neovascularization (CorNV). The pathogenesis of inflammatory CorNV is not fully understood yet, and our previous study implicated that serum amyloid A (Saa) 1 (Saa1) and Saa3 were among ...
Sheng-Wei Ren, Xia Qi, Chang-Kai Jia, Yi-Qiang Wang   +3 more
doaj   +1 more source

Discovery of Encrypted Peptides in a Human Matrix Metallopeptidase

JACS Au
The human proteome represents a vast, largely untapped source of encrypted bioactive peptides with therapeutic potential. Here, we report the discovery and functional characterization of three antimicrobial encrypted peptides (EPs) derived from human matrix metallopeptidase-19 (residues 1-19, 1-33, and 247-279).
Gaglione R., Schibeci M., Piccolo E., Culurciello R., Zannella C., Mensitieri F., Dal Piaz F., Cafaro V., De Filippis A., Pizzo E., Notomista E., Torres M. D. T., de la Fuente-Nunez C., Arciello A.   +13 more
openaire   +3 more sources

P2X7 receptor antagonism modulates IL-1β and MMP9 in human atherosclerotic vessels

Scientific Reports, 2017
In atherosclerosis, matrix metallopeptidases (MMPs) contribute to plaque rupture through weakening of the fibrous cap. Pleiotropic P2X purinoceptor 7 (P2X7), expressed in the carotid plaque (PL), is involved in interleukin 1 beta (IL-1β) release that may
Maria Lombardi, Maria Elena Mantione, Domenico Baccellieri, David Ferrara, Renata Castellano, Roberto Chiesa, Ottavio Alfieri, Chiara Foglieni   +7 more
doaj   +1 more source

Association of Matrix Metallopeptidase-2 Promoter Polymorphisms With the Risk of Childhood Leukemia [PDF]

Anticancer Research, 2019
The association of matrix metalloproteinase-2 (MMP-2) genotypes with adult leukemia has been reported only once, but never for childhood leukemia. This study aimed to determine the role of MMP-2 promoter -1306 (rs243865) and -735 (rs2285053) genotypes in childhood leukemia risk.This case-control study included 266 patients and 266 age- and gender ...
Pei-Chen, Hsu, Jen-Sheng, Pei, Chao-Chun, Chen, Wen-Shin, Chang, Chien-Chung, Kuo, Shun-Ping, Cheng, Chia-Wen, Tsai, DA-Tian, Bau, Chi-Li, Gong   +8 more
openaire   +2 more sources

Co-Catalytic Metallopeptidases as Pharmaceutical Targets [PDF]

, 2003
Understanding the reaction mechanism of co-catalytic metallopeptidases provides a starting point for the design and synthesis of new molecules that can be screened as potential pharmaceuticals. Many of the enzymes that contain co-catalytic metallo-active
Holz, Richard C., Swierczek, Sabina I., Bzymek, Krzysztof P.   +2 more
core  

Discovery, validation and sequencing of urinary peptides for diagnosis of liver fibrosis—A multicentre study

EBioMedicine, 2020
Background: Liver fibrosis is a consequence of chronic inflammation and is associated with protein changes within the hepatocytes structure. In this study, we aimed to investigate if this is reflected by the urinary proteome and can be explored to ...
Ayman S. Bannaga, Jochen Metzger, Ioannis Kyrou, Torsten Voigtländer, Thorsten Book, Jesus Melgarejo, Agnieszka Latosinska, Martin Pejchinovski, Jan A. Staessen, Harald Mischak, Michael P. Manns, Ramesh P. Arasaradnam   +11 more
doaj   +1 more source

Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo, Josefin Kenrick, Angeles S. Galindo‐Feria, Antonella Notarnicola, Ana Daniela Ulloa Navas, Irene Peralta‐Garcia, Orane Demuynck, Andrea Kemp, Valérie Leclair, Karin Lodin, Eveline Van Gompel, Lara Dani, Fabricio Espinosa‐Ortega, Maryam Dastmalchi, Leonid Padyukov, Charlotta Preger, María Bueno Álvez, Mathias Uhlén, Peter Nilsson, Fredrik Edfors, Lina‐Marcela Diaz‐Gallo, Elisa Pin, Ingrid E. Lundberg, Begum Horuluoglu   +23 more
wiley   +1 more source

Data matrix: Acropyga_UCE-944-matrix

, 2016
Data matrix: Acropyga_UCE-944 ...
John S. LaPolla (134265), Michael G. Branstetter (609954), Michael W. Lloyd (413916), Bonnie B. Blaimer (431703), Sean G. Brady (3248967)   +4 more
core   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source