Results 111 to 120 of about 198,679 (292)

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

Isoliquiritigenin Inhibits IL-1β-Induced Production of Matrix Metalloproteinase in Articular Chondrocytes

Molecular Therapy: Methods & Clinical Development, 2018
Osteoarthritis (OA) is a major joint disease in which inflammatory cytokine interleukin-1β (IL-1β) and matrix metalloproteinases (MMPs) play a pivotal role. Isoliquiritigenin has been reported to have anti-inflammation activity. In this study, the effect
Lei Zhang, Shiyun Ma, Hang Su, Jiaxiang Cheng   +3 more
doaj   +1 more source

Regulation of matrix-metalloproteinase 9 (MMP-9) in glomerular mesangial cells

, 2004
Remodeling of extracellular matrix (ECM) is an important physiologic feature of normal growth and development. In addition to this critical function in physiology many diseases have been associated with an imbalance of ECM synthesis and degradation.
Akool, El-Sayed
core  

MMP-10 is overexpressed, proteolytically active and a potential target for therapeutic intervention in human lung carcinomas

, 2004
NoMatrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor development and expansion. This study analysed MMP-10 protein expression and activity in human lung tumors of various grade, stage, and type to ...
Tijani, S., Jason H. Gill, Martin, Sandie W., Alan J. Mearns, Alan Anthoney, Mearns, A.J., Kirwan, I.G, Anikin, V.A., Anikin, V.A, Gill, J.H, Tijani, S, Loadman, Paul, Anthoney, A, Jill M. Seargent, Sandie W. Martin, Mearns, Alan J., Kirwan, Ian G., Seargent, Jill M., Anthoney, Alan, Loadman, P.M, Seargent, J.M, Mearns, A.J, Anikin, Vladimir A., Ian G. Kirwan, Tijani, Sidiq, Bibby, M.C, Martin, S.W, Sidiq Tijani, Bibby, Michael C., Loadman, Paul M., Gill, Jason H., Michael C. Bibby, Paul M. Loadman, Vladimir A. Anikin   +33 more
core   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

The Role of Matrix Metalloproteinase 13 and Vitamin D in Osteoarthritis: A Hospital-Based Observational Study. [PDF]

Cureus, 2023
Kumar P, Kumar S, Abhilasha A, Singh A, Kumar U.   +4 more
europepmc   +1 more source

Identification of novel molecular scaffolds for the design of MMP-13 inhibitors through Virtual Screening Methods

, 2010
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly patients. It is characterized by progressive loss of articular cartilage that eventually leads to denudation of the joint surface.
La Pietra, Valeria
core  

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Molecular Dynamics Simulations of Matrix Metalloproteinase 13 and the Analysis of the Specificity Loop and the S1'-Site. [PDF]

Int J Mol Sci, 2023
Choi JY, Chung E.
europepmc   +1 more source