Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis [PDF]
International Journal of Molecular Sciences, 2021 Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen.
Qichan Hu, Melanie Ecker
exaly +6 more sources
Indole Inhibitors of MMP-13 for Arthritic Disorders [PDF]
ACS Omega, 2021 Here, we described the design, by fragment merging and multiparameter optimization, of selective MMP-13 inhibitors that display an appropriate balance of potency and physicochemical properties to qualify as tool compounds suitable for in vivo testing.
Steven J. Taylor +21 more
doaj +5 more sources
Clinical value of microRNA-135a and MMP-13 in colon cancer. [PDF]
Oncol Lett, 2021 The aim of the present study was to investigate the expression and prognostic value of microRNA-135a (miR-135a) and matrix metalloproteinase-13 (MMP-13) in serum of colon cancer (CC). A total of 117 cases of patients admitted to Sheng Li Oil Field Central Hospital from May 2015 to May 2017 were enrolled in the research group (RG), and 120 cases of ...
Zhou X, Yang D, Ding X, Xu P.
europepmc +4 more sources
Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13 [PDF]
Scientific Reports, 2023 Osteoarthritis (OA) is the most common joint disease associated with articular cartilage destruction. Matrix metalloproteinase-13 (MMP-13) has an essential role in OA pathogenesis by degradation of collagen II, a major component of articular cartilage ...
Aya Miyauchi +7 more
doaj +2 more sources
MMP-13, VEGF, and Disease Activity in a Cohort of Rheumatoid Arthritis Patients [PDF]
Diagnostics, 2023 Identifying certain serum biomarkers associated with the degree of rheumatoid arthritis (RA) activity can provide us with a more accurate view of the evolution, prognosis, and future quality of life for these patients. Our aim was to analyze the presence
Mihail Virgil Boldeanu +12 more
doaj +2 more sources
Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1. [PDF]
Int J Mol Sci, 2022 Mitogen-activated protein kinase phosphatase-1 (MKP-1) is upregulated in inflammation and reduces the activity of proinflammatory mitogen-activated protein kinases (MAP kinases) by dephosphorylation. MAP kinases are intracellular signaling pathways that mediate the cellular effects of proinflammatory cytokines. In the present study, we investigated the
Lehtola T +7 more
europepmc +5 more sources
MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis. [PDF]
J Nanobiotechnology, 2020 Abstract Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environment and overexpressed matrix metalloproteinases-13 (MMP-13) are typical markers in osteoarthritis (OA), which enables
Lan Q +9 more
europepmc +5 more sources
Collagenase-3 (MMP-13) Expression in Cutaneous Malignant Melanoma
The International Journal of Biological Markers, 2005 Background Matrix metalloproteases (MMPs), enzymes with the ability to degrade the extracellular matrix, play an important role in tissue invasion by cutaneous malignant melanoma (CMM).
M.D. Corte +6 more
doaj +3 more sources
The Role of Matrix Metalloproteinases (MMP-8, MMP-9, MMP-13) in Periodontal and Peri-Implant Pathological Processes [PDF]
International Journal of Molecular Sciences, 2022 Ionut Luchian +2 more
exaly +2 more sources
Potential Value of Matrix Metalloproteinase-13 as a Biomarker for Osteoarthritis
Frontiers in Surgery, 2021 Background: Emerging knowledge has highlighted the role of matrix metalloproteinase (MMP)-13 in osteoarthritis (OA); however, the suitability of MMP-13 as a biomarker for OA remains unclear.
Xing Xin +16 more
doaj +1 more source