Results 121 to 130 of about 198,679 (292)

Tumor-derived Matrix Metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer-3

, 2011
Fibroblast cells . High levels of MMP-13 protein exclusively in the cytoplasm of the cancer cells . The brown color represents the IHC staining of MMP-13. The blue color represents the nuclear counterstain. × 400. Insets of and show a section of the each
Yun Niu (85792), Baocun Sun (64658), Hongtao Li (85789), Bin Zhang (64682), Yanxue Liu (85785), Wenfeng Cao (85786), Fei Zhang (85787), Xishan Hao (85794), Xuchen Cao (85784), Li Fu (85791), Liansheng Ning (85790), Shiwu Zhang (85788), Ruifang Niu (85793)   +12 more
core   +1 more source

Serum levels of matrix metalloproteinases-2 and-9 and their tissue inhibitors in inflammatory neuromuscular disorders [PDF]

, 2006
We monitored serum levels of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) before and during intravenously applied immunoglobulin (IVIG) therapy in 33 patients with chronic immune-mediated neuropathies and myopathies and 15 ...
Mueller-Felber, W., Schoser, B. G. H., Hurnaus, S., Pongratz, D.   +3 more
core   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Expressions of insulin-like growth factor-1, interleukin-1β, and matrix metalloproteinase-13 in patients with knee osteoarthritis and their associations with the severity

Romanian Journal of Laboratory Medicine
A key factor in the pathogenesis of osteoarthritis is an imbalance in cytokines, favoring proinflammatory activity. This study aimed to explore the expressions of insulin-like growth factor-1 (IGF-1), interleukin-1β (IL-β) and matrix metalloproteinase-13
Zheng Nan
doaj   +1 more source

Fractional Excretion of Survivin, Extracellular Matrix Metalloproteinase Inducer, and Matrix Metalloproteinase 7 in Children with Chronic Kidney Disease

, 2016
Background: Epithelial–mesenchymal transition (EMT) is defined as a transformation of tubular epithelial cells into mesenchymal ones. These cells migrate through the extracellular matrix and change into active myofibroblasts, which are responsible for ...
Agnieszka Bargenda, Kinga Musiał, Danuta Zwolińska   +2 more
core  

Variants within the MMP3 gene are associated with achilles tendinopathy: possible interaction with the COL5A1 gene

, 2009
Objectives: Sequence variation within the COL5A1 and TNC genes are known to associate with Achilles tendinopathy. The primary aim of this case-control genetic association study was to investigate whether variants within the matrix metalloproteinase 3 ...
Ribbans, William J, Raleigh, S M, Ribbans, W J, Smith, R K, Collins, M, Raleigh, Stuart M, Smith, R K W, Schwellnus, M P, van der Merwe, L, Ribbans, William J; id_orcid, Northampton   +10 more
core   +1 more source

Exogenously added GPI-anchored tissue inhibitor of matrix metal loproteinase-1 (TIMP-1) displays enhanced and novel biological activities [PDF]

, 2004
The family of tissue inhibitors of metalloproteinases (TIMPs) exhibits diverse physiological/biological functions including the inhibition of active matrix metalloproteinases, regulation of proMMP activation, cell growth, and the modulation of ...
P.J. Nelson, Belen Vicente, A., R. Djafarzadeh, Mojaat, A., Nelson, P. J., Djafarzadeh, R., Lüttichau, I. von, I. von Lüttichau, A. Belen Vicente, A. Mojaat   +9 more
core   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Matrix metalloproteinase 13 (MMP13) [PDF]

Science-Business eXchange, 2009
openaire   +3 more sources

Matrix metalloproteinase-13 downregulation and potential cartilage protective action of the Korean Red Ginseng preparation

Journal of Ginseng Research, 2015
Background: The present study was designed to prepare and find the optimum active preparation or fraction from Korea Red Ginseng inhibiting matrix metalloproteinase-13 (MMP-13) expression, because MMP-13 is a pivotal enzyme to degrade the collagen matrix
Je Hyeong Lee, Omer Shehzad, Sung Kwon Ko, Yeong Shik Kim, Hyun Pyo Kim   +4 more
doaj   +1 more source