Results 241 to 250 of about 73,669,415 (286)

Effects of Extracorporeal Shock Wave Therapy on Tendon Integrity, Biomechanical Strength, Matrix Remodeling, Inflammation, Angiogenesis, and Tenogenic Differentiation in Rotator Cuff Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Extracorporeal shock wave therapy (ESWT) improves tendon‐bone healing after rotator cuff injury (RCI), but its underlying cellular mechanisms remain unknown. This study aimed to explore the therapeutic effects of ESWT on RCI, with a particular focus on endothelial cells and tenocytes.
Hua Wang, Fei Wu, Jia‐Qing Miao
wiley   +1 more source

Autologous minimally manipulated adipose‐derived stromal vascular fraction in knee osteoarthritis: Lasting symptom relief and imaging evidence from a 12‐month prospective study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate the safety and efficacy of intra‐articular autologous transplantation of adipose‐derived connective tissue micrografts rich in stromal vascular fraction (CTM‐SVF), obtained using an enzyme‐free system (Hy‐Tissue® SVF) for knee osteoarthritis (OA). Methods Thirty patients (mean age of 53.3 ± 6.4 years) with Kellgren–Lawrence
Laura Mangiavini, Nicolò Rossi, Riccardo Giorgino, Francesco Borelli, Alessandra Colombini, Paola De Luca, Simona Landoni, Luca Maria Sconfienza, Carmelo Messina, Irene Beriotto, Giuseppe M. Peretti, Laura de Girolamo   +11 more
wiley   +1 more source

Persistent magnetic resonance imaging‐derived static anterior tibial translation after anterior cruciate ligament reconstruction is associated with elevated cartilage T2 relaxation times but not serum biomarkers

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Persistent, static anterior tibial translation (sATT) alterations following anterior cruciate ligament reconstruction (ACLR) may influence cartilage health. T2 relaxation times and serum biomarkers of cartilage degradation/bone resorption provide insight into osteoarthritis development.
Manuel Angel Romero‐Padron, Tyler Kallman, Mark Amirtharaj, Neal Weldon, Melissa Manzer, Balasrinivasa Rao Sajja, Matthew Alan Tao, Elizabeth Wellsandt   +7 more
wiley   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

Metabolic‐Epigenetic Coupling in Aortic Aneurysm and Aortic Dissection: GLS1 and SLC1A5 as Guardians of VSMC Homeostasis

iNew Medicine, EarlyView.
Yu Zeng, Jifeng Zhang, Haocheng Lu
wiley   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

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Immunohistochemical Expression of Matrix Metalloproteinase 13 in Chronic Periodontitis

International Journal of Periodontics & Restorative Dentistry, 2014
The extracellular matrix is a complex integrated system responsible for the physiologic properties of connective tissue. Collagen is the major extracellular component that is altered in pathologic conditions, mainly periodontitis. The destruction involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs), which play a key role in ...
Alapati, Nagasupriya, Donimukkala Bheemalingeswara, Rao, Manyam, Ravikanth, Nalabolu Govind, Kumar, Cinnamanoor Rajmani, Ramachandran, Thillai Rajashekaran, Saraswathi   +5 more
openaire   +2 more sources

The Structure, Regulation, and Function of Human Matrix Metalloproteinase-13

Critical Reviews in Biochemistry and Molecular Biology, 2002
Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme that belongs to a large family of extracellular matrix-degrading endopeptidases that are characterized by a zinc-binding motif at their catalytic sites. MMP-13 has a key role in the MMP activation cascade and appears to be critical in bone metabolism and homeostasis.
Matthew F, Leeman, Stephanie, Curran, Graeme I, Murray   +2 more
openaire   +2 more sources

Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13

Journal of Medicinal Chemistry, 2011
Matrix metalloproteases (MMPs) play an important role in cartilage homeostasis under both normal and inflamed disease states and, thus, have become attractive targets for the treatment of arthritic diseases. Herein, we describe the identification of a potent, selective MMP-13 inhibitor, developed using fragment-based structure-guided lead ...
Taylor, Steven J., Abeywardane, Asitha, Liang, Shuang, Muegge, Ingo, Padyana, Anil K., Xiong, Zhaoming, Hill-Drzewi, Melissa, Farmer, Bennett, Li, Xiang, Collins, Brandon, Li, John Xiang, Heim-Riether, Alexander, Proudfoot, John, Zhang, Qiang, Goldberg, Daniel, Zuvela-Jelaska, Ljiljana, Zaher, Hani, Li, Jun, Farrow, Neil A.   +18 more
openaire   +3 more sources