Results 251 to 260 of about 198,679 (292)

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Evaluation of collagenase-3 matrix metalloproteinase-13 gene-associated polymorphisms 11A/12A and -77A/G and its associated alleles with and without periodontitis.

J Indian Soc Periodontol, 2018
Prasanna JS, Aishwarya MD, Karunakar P, Rekharani K, Vijayalakshmi B, Jharna P.   +5 more
europepmc   +1 more source

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Immunohistochemical Expression of Matrix Metalloproteinase 13 in Chronic Periodontitis

International Journal of Periodontics & Restorative Dentistry, 2014
The extracellular matrix is a complex integrated system responsible for the physiologic properties of connective tissue. Collagen is the major extracellular component that is altered in pathologic conditions, mainly periodontitis. The destruction involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs), which play a key role in ...
Alapati, Nagasupriya, Donimukkala Bheemalingeswara, Rao, Manyam, Ravikanth, Nalabolu Govind, Kumar, Cinnamanoor Rajmani, Ramachandran, Thillai Rajashekaran, Saraswathi   +5 more
openaire   +2 more sources

The Structure, Regulation, and Function of Human Matrix Metalloproteinase-13

Critical Reviews in Biochemistry and Molecular Biology, 2002
Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme that belongs to a large family of extracellular matrix-degrading endopeptidases that are characterized by a zinc-binding motif at their catalytic sites. MMP-13 has a key role in the MMP activation cascade and appears to be critical in bone metabolism and homeostasis.
Matthew F, Leeman, Stephanie, Curran, Graeme I, Murray   +2 more
openaire   +2 more sources

Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13

Journal of Medicinal Chemistry, 2011
Matrix metalloproteases (MMPs) play an important role in cartilage homeostasis under both normal and inflamed disease states and, thus, have become attractive targets for the treatment of arthritic diseases. Herein, we describe the identification of a potent, selective MMP-13 inhibitor, developed using fragment-based structure-guided lead ...
Steven J, Taylor, Asitha, Abeywardane, Shuang, Liang, Ingo, Muegge, Anil K, Padyana, Zhaoming, Xiong, Melissa, Hill-Drzewi, Bennett, Farmer, Xiang, Li, Brandon, Collins, John Xiang, Li, Alexander, Heim-Riether, John, Proudfoot, Qiang, Zhang, Daniel, Goldberg, Ljiljana, Zuvela-Jelaska, Hani, Zaher, Jun, Li, Neil A, Farrow   +18 more
openaire   +2 more sources

Regulation of matrix metalloproteinase 13 expression by androgen in prostate cancer

Oncology Reports, 2004
The matrix metalloproteinases (MMPs) are members of a family of endopeptidases that are able to degrade extra-cellular matrix. MMPs and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs), play a key role in the migration of normal and malignant cell.
Pang, See Tong, Flores-Morales, Amilcar, Skoog, Lambert, Chuan, Yin Choy, Nordstedt, Gunnar, Pousette, Åke   +5 more
openaire   +3 more sources

Serum levels of matrix metalloproteinase‐13 in patients with eosinophilic fasciitis

The Journal of Dermatology, 2014
AbstractMatrix metalloproteinase‐13 (MMP‐13), a member of the collagenase family, has been implicated in the pathogenesis of connective tissue diseases characterized by extracellular matrix remodeling. Since serum MMP‐13 levels reflect disease severity of systemic sclerosis and localized scleroderma, we evaluated the clinical significance of serum MMP ...
Yoshihide, Asano, Hironobu, Ihn, Masatoshi, Jinnin, Zenshiro, Tamaki, Kunihiko, Tamaki, Shinichi, Sato   +5 more
openaire   +2 more sources

Elevated Expression of Matrix Metalloproteinase-13 in Abdominal Aortic Aneurysms

Annals of Vascular Surgery, 2004
Destructive remodeling of extracellular matrix has been shown to be present in aneurysmal abdominal aorta. We used real-time quantitative reverse transcriptase polymerase chain reaction to determine the relative expression of matrix metalloproteinase-13 (MMP13) in aortic tissue samples from patients who underwent abdominal aortic aneurysm repair ...
Gerard, Tromp, Zoran, Gatalica, Magdalena, Skunca, Ramon, Berguer, Thomas, Siegel, Ronald A, Kline, Helena, Kuivaniemi   +6 more
openaire   +2 more sources