Results 251 to 260 of about 73,669,415 (286)

Regulation of matrix metalloproteinase 13 expression by androgen in prostate cancer

Oncology Reports, 2004
The matrix metalloproteinases (MMPs) are members of a family of endopeptidases that are able to degrade extra-cellular matrix. MMPs and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs), play a key role in the migration of normal and malignant cell.
Pang, See Tong, Flores-Morales, Amilcar, Skoog, Lambert, Chuan, Yin Choy, Nordstedt, Gunnar, Pousette, Åke   +5 more
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Serum levels of matrix metalloproteinase‐13 in patients with eosinophilic fasciitis

The Journal of Dermatology, 2014
AbstractMatrix metalloproteinase‐13 (MMP‐13), a member of the collagenase family, has been implicated in the pathogenesis of connective tissue diseases characterized by extracellular matrix remodeling. Since serum MMP‐13 levels reflect disease severity of systemic sclerosis and localized scleroderma, we evaluated the clinical significance of serum MMP ...
Yoshihide, Asano, Hironobu, Ihn, Masatoshi, Jinnin, Zenshiro, Tamaki, Kunihiko, Tamaki, Shinichi, Sato   +5 more
openaire   +2 more sources

Elevated Expression of Matrix Metalloproteinase-13 in Abdominal Aortic Aneurysms

Annals of Vascular Surgery, 2004
Destructive remodeling of extracellular matrix has been shown to be present in aneurysmal abdominal aorta. We used real-time quantitative reverse transcriptase polymerase chain reaction to determine the relative expression of matrix metalloproteinase-13 (MMP13) in aortic tissue samples from patients who underwent abdominal aortic aneurysm repair ...
Gerard, Tromp, Zoran, Gatalica, Magdalena, Skunca, Ramon, Berguer, Thomas, Siegel, Ronald A, Kline, Helena, Kuivaniemi   +6 more
openaire   +2 more sources

Parathyroid hormone increases the expression level of matrix metalloproteinase-13 in vivo

Journal of Bone and Mineral Metabolism, 2001
Parathyroid hormone (PTH) increases serum calcium (Ca) by enhancing bone resorption and renal Ca reabsorption. However, detailed mechanisms of enhanced bone resorption by PTH remain to be elucidated. Although PTH has been shown to increase the expression level of osteoblastic matrix metalloproteinase (MMP)-13 in vitro, only limited results are ...
M, Uchida, H, Yamato, Y, Nagai, H, Yamagiwa, T, Hayami, K, Tokunaga, N, Endo, H, Suzuki, K, Obara, A, Fujieda, H, Murayama, S, Fukumoto   +11 more
openaire   +2 more sources

Development of a Neutralizing Antibody Specific for the Active Form of Matrix Metalloproteinase-13

Biochemistry, 2012
Matrix metalloproteinase-13 (MMP-13) is important in the pathology of osteoarthritis (OA). Although MMP-13 is considered a therapeutic target for OA, it is unclear how MMP-13 activity is regulated by the system that comprises various proteinases and their inhibitors.
Shoichi, Naito, Tatsuya, Takahashi, Junji, Onoda, Akira, Yamauchi, Taeko, Kawai, Junji, Kishino, Shoji, Yamane, Ikuo, Fujii, Naoshi, Fukui, Yoshito, Numata   +9 more
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Differential expression of matrix metalloproteinase-13 in mucinous and nonmucinous colorectal carcinomas

Annals of Diagnostic Pathology, 2013
Colorectal carcinoma (CRC) is a major health problem all over the world. Mucinous CRCs are known to have a peculiar behavior and genetic derangements. This study aimed to investigate matrix metalloproteinase (MMP)-13 expression in mucinous and nonmucinous CRCs.
Abd Al-Rahman Mohammad, Foda, Amira K, El-Hawary, Azza, Abdel-Aziz   +2 more
openaire   +2 more sources

Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis

Arthritis & Rheumatism, 2000
To correlate the increased collagenase production previously seen in chondrocytes isolated from osteoarthritic (OA) lesions and the expression of cytokines and cytokine receptors.Chondrocytes were isolated from OA cartilage and characterized for synthesis of collagenases, cytokines, and cytokine receptors by Northern and Western blot analyses, RNA ...
B V, Shlopov, M L, Gumanovskaya, K A, Hasty   +2 more
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Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice

Biochemical and Biophysical Research Communications, 2007
Vascular and cellular invasion into the cartilage is a critical step in the fracture healing. Matrix metalloproteinase-13 (MMP-13) is a member of the zinc-dependent endopeptidase family and plays an important role in remodeling of extracellular matrix.
Naoto, Kosaki, Hironari, Takaishi, Satoru, Kamekura, Tokuhiro, Kimura, Yasunori, Okada, Li, Minqi, Norio, Amizuka, Ung-Il, Chung, Kozo, Nakamura, Hiroshi, Kawaguchi, Yoshiaki, Toyama, Jeanine, D'Armiento   +11 more
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The cloning and functional analysis of canine matrix metalloproteinase-13 gene promoter

Gene, 2002
A fragment of the 5' untranslated region corresponding to the canine matrix metalloproteinase-13 (MMP-13), collagenase-3 gene promoter has been isolated and characterized in rat cardiocytes to investigate the role of MMP-13 in cardiac disease. The promoter fragment (1.5 kb) demonstrated regions of sequence homology with the collagenase gene promoter ...
Sarah E, Campbell, Arvind, Sood, David J, Argyle, Lubna, Nasir, Sally Anne, Argyle, David, Bennett   +5 more
openaire   +2 more sources

Transactivation by Runt related factor-2 of matrix metalloproteinase-13 in astrocytes

Neuroscience Letters, 2009
We have previously shown functional expression by osteoblasts of signaling machineries required for neurotransmission in the brain. In this study, we have evaluated possible functional expression of different osseous genes in the brain. In embryonic and adult mouse brains, mRNA expression was invariably seen for the master regulator of osteoblastic ...
Takeshi, Takarada, Yukio, Yoneda
openaire   +2 more sources