Results 71 to 80 of about 73,669,415 (286)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

EMBO Molecular Medicine, 2013
Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases.
Roosmarijn E. Vandenbroucke, Eline Dejonckheere, Filip Van Hauwermeiren, Sofie Lodens, Riet De Rycke, Elien Van Wonterghem, An Staes, Kris Gevaert, Carlos López‐Otin, Claude Libert   +9 more
doaj   +1 more source

Effect of Progesterone on Expression of MMP7 and MMP13 in Lungs of Female Mice

Iranian Journal of Allergy, Asthma and Immunology, 2018
Gender medicine is a new era of science which focuses on the impact of sex hormones and gender on normal physiology, pathobiology and clinical features of diseases.
Elahe Izadi, Fateme Vafashoar, Paria Jorbozedar, Pendar Safari, Mohamad Ali Assarehzadegan, Hadi Poormoghim, Jalil Kuhpayezadeh, Nazanin Mojtabavi   +7 more
doaj   +1 more source

Matrix Metalloproteinase‐13 Is Highly Expressed in Destructive Periodontal Disease Activity

Journal of Periodontology, 2006
Background: Matrix metalloproteinases (MMPs) participate in extracellular matrix degradation in physiological and pathological conditions. The available evidence suggests that MMP‐13 plays a significant role in both the initiation and progress of bone resorption.
Hernández Ríos, Emma, Valenzuela, María Antonieta, López Otin, Carlos, Alvarez, Jesús, López, José Manuel, Vernal Astudillo, Rolando, Gamonal Aravena, Jorge Antonio   +6 more
openaire   +5 more sources

Modified platelet deposition on matrix metalloproteinase 13 digested collagen I [PDF]

Journal of Thrombosis and Haemostasis, 2015
Atherothrombosis underlies acute coronary syndromes, including unstable angina and acute myocardial infarction. Within the unstable plaque, monocytes express collagenolytic matrix metalloproteinases (MMPs), including MMP-13, which degrades fibrous collagen. Following rupture, vessel wall components including degraded collagen are exposed to circulating
Howes, J-M, Pugh, N, Knäuper, V, Farndale, RW   +3 more
openaire   +2 more sources

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Rational Design of Matrix Metalloproteinase-13 Activatable Probes for Enhanced Specificity [PDF]

ACS Chemical Biology, 2013
Because of the important roles that matrix metalloproteinases (MMPs) play in tumor invasion and metastasis, various activatable optical probes have been developed to visualize MMP activities in vitro and in vivo. Our recently developed MMP-13 activatable probe, l-MMP-P12, has been successfully applied to image the expression and inhibition of MMPs in a
Zhu, Lei, Ma, Ying, Kiesewetter, Dale O., Wang, Ye, Lang, Lixin, Lee, Seulki, Niu, Gang, Chen, Xiaoyuan   +7 more
openaire   +3 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice

Neurobiology of Disease, 2016
New neuroreparative and neuroprotective therapies are being sought to treat stroke patients. One approach is the remodeling of extracellular matrix, which participates in both brain injury and neurovascular repair when matrix metalloproteinases (MMPs ...
Feifei Ma, Pablo Martínez-San Segundo, Verónica Barceló, Anna Morancho, Marina Gabriel-Salazar, Dolors Giralt, Joan Montaner, Anna Rosell   +7 more
doaj   +1 more source

Matrix metalloproteinase 13 (MMP13) is a direct target of osteoblast-specific transcription factor osterix (Osx) in osteoblasts. [PDF]

PLoS ONE, 2012
Osterix (Osx) is an osteoblast-specific transcription factor required for bone formation and osteoblast differentiation from mesenchymal stem cells. In Osx-null mice, no bone formation occurs. Matrix metalloproteinase 13 (MMP13) is a member of the matrix
Chi Zhang, Wanjin Tang, Yang Li
doaj   +1 more source