Results 51 to 60 of about 73,669,415 (286)

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds [PDF]

Bioorganic & Medicinal Chemistry Letters, 2011
Matrix metalloproteinase-13 (MMP-13) has been implicated as the protease responsible for collagen degradation in cartilage during osteoarthritis (OA). Compounds that inhibit the metalloproteinase at the Zn binding site typically lack specificity among MMP family members.
Joshua, Roth, Dmitriy, Minond, Etzer, Darout, Qin, Liu, Janelle, Lauer, Peter, Hodder, Gregg B, Fields, William R, Roush   +7 more
openaire   +3 more sources

The effect of Satureja sahendica Bornm essential oil on the expression of metalloproteases1, 2, 9 and 13 in bovine fibroblast - like syniviocytes [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2023
Introduction: Osteoarthritis is a progressive, age-related disease characterized by cartilage destruction, subchondral bone formation, and inflammation of the synovial membrane.
Hossein Maghsoudi, Enayatollah Yazdanpanah, Ali Moheb   +2 more
doaj  

N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells] [PDF]

, 2004
Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability to inhibit apoptosis of HSC via matrix ...
Iredale, John P., Julian Waung, Derek Mann, R Christopher Benyon, Collins, Jane, Arthur, Michael J.P., Murphy, Frank, Nagase, Hideaki, Hideaki Nagase, John P Iredale, Mann, Derek, Frank Murphy, Waung, Julian, Jane Collins, Benyon, R. Christopher, Michael JP Arthur   +15 more
core   +1 more source

MMP-13, VEGF, and Disease Activity in a Cohort of Rheumatoid Arthritis Patients

Diagnostics, 2023
Identifying certain serum biomarkers associated with the degree of rheumatoid arthritis (RA) activity can provide us with a more accurate view of the evolution, prognosis, and future quality of life for these patients. Our aim was to analyze the presence
Mihail Virgil Boldeanu, Lidia Boldeanu, Oana Mariana Cristea, Dana Alexandra Ciobanu, Sabin Ioan Poenariu, Anda Lorena Dijmărescu, Andreea Lili Bărbulescu, Vlad Pădureanu, Teodor Nicuşor Sas, Ștefan Cristian Dinescu, Florentin Ananu Vreju, Horațiu Valeriu Popoviciu, Răzvan Adrian Ionescu   +12 more
doaj   +1 more source

Bone Marrow-derived Myofibroblasts Are the Providers of Pro-invasive Matrix Metalloproteinase 13 in Primary Tumor

Neoplasia: An International Journal for Oncology Research, 2012
Carcinoma-associated fibroblasts are key contributors of the tumor microenvironment that regulates carcinoma progression. They consist of a heterogeneous cell population with diverse origins, phenotypes, and functions.
Julie Lecomte, Anne Masset, Silvia Blacher, Ludovic Maertens, André Gothot, Marie Delgaudine, Françoise Bruyère, Oriane Carnet, Jenny Paupert, Martin Illemann, Jean-Michel Foidart, Ida K Lund, Gunilla Høyer-Hansen, Agnes Noel   +13 more
doaj   +1 more source

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice [PDF]

Development, 2004
The assembly and degradation of extracellular matrix (ECM) molecules are crucial processes during bone development. In this study, we show that ECM remodeling is a critical rate-limiting step in endochondral bone formation. Matrix metalloproteinase (MMP) 13 (collagenase 3) is poised to play a crucial role in bone formation and remodeling because of its
Stickens, Dominique, Behonick, Danielle J, Ortega, Nathalie, Heyer, Babette, Hartenstein, Bettina, Yu, Ying, Fosang, Amanda J, Schorpp-Kistner, Marina, Angel, Peter, Werb, Zena   +9 more
openaire   +3 more sources

Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis [PDF]

, 2014
Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches.
Sandhu, G, Christopher H. Woelk, Carlton A. W. Evans, Gurjinder Sandhu (161147), Borislav D. Dimitrov (687966), Gurjinder Sandhu, Woelk Christopher H., Liku B. Tezera, Akul Singhania, Thomas, Richard, Agranoff Dan, Sandhu Gurjinder, Liku B. Tezera (405129), Paul T. Elkington, Christopher H. Woelk (195217), Tezera, LB, Friedland Jon S., Jon S Friedland, Sathyamoorthy, Tarangini, Dimitrov, Borislav D., Sathyamoorthy, T, Singhania, A, Elkington, Paul T., Evans Carlton A. W., Agranoff, Dan, Evans, CAW, Richard Thomas, Elkington Paul T., Dimitrov, BD, Borislav D Dimitrov, Friedland, Jon S., Carlton A. W. Evans (687967), Christopher H Woelk, Dan Agranoff, Paul T Elkington, Paul T. Elkington (364501), Tarangini Sathyamoorthy (687964), Agranoff, D, Jon S. Friedland (161158), Tezera, Liku B., Sathyamoorthy Tarangini, Woelk, Christopher H., Borislav D. Dimitrov, Richard Thomas (687965), Akul Singhania (502117), Evans, Carlton A.W., Singhania, Akul, Jon S. Friedland, Tarangini Sathyamoorthy, Liku B Tezera, Sandhu, Gurjinder, Friedland, JS, Carlton A W Evans, Tezera Liku B., Thomas, R, Elkington, PT, Thomas Richard, Woelk, CH, Singhania Akul, Dan Agranoff (377996), Dimitrov Borislav D.   +60 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Proteomic biomarkers in rotator cuff disease: Current evidence and translational implications from a systematic review and network analysis

Journal of Orthopaedic Translation
Background: Rotator cuff disorders are among the most common causes of shoulder pain and dysfunction, primarily driven by chronic inflammation and degenerative changes in tendon tissue.
Elvira Immacolata Parrotta, Giorgia Lucia Benedetto, Giovanni Cuda, Raffaele Covello, Umile Giuseppe Longo, Arianna Carnevale, Olimpio Galasso, Giorgio Gasparini, Michele Mercurio   +8 more
doaj   +1 more source

Matrix metalloproteinase 13 activity is associated with poor prognosis in colorectal cancer [PDF]

Journal of Clinical Pathology, 2002
Aims: The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes collectively capable of degrading all extracellular matrix components, in particular fibrillar collagen. The importance of this group of proteins in the processes of tumour invasion and metastasis is now widely acknowledged.
M F, Leeman, J A, McKay, G I, Murray
openaire   +2 more sources