Results 31 to 40 of about 198,679 (292)

Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model

Pharmaceuticals, 2021
Arthritis is a common inflammatory disease that causes pain, stiffness, and joint swelling. Here, we investigated the ameliorative effects of loganin on arthritis in vitro and in vivo. A single bioactive compound was fractionated and isolated from Cornus
Eunkuk Park, Chang Gun Lee, Seung Hee Yun, Seokjin Hwang, Hyoju Jeon, Jeonghyun Kim, Subin Yeo, Hyesoo Jeong, Seong-Hoon Yun, Seon-Yong Jeong   +9 more
doaj   +1 more source

Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]

, 2006
Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Helmut Kolb, Krell, Hans-Willi, Kolb, Helmut, Heidinger, Michael, Michael Heidinger, Hans-Willi Krell, Marianne Jochum, Jochum, Marianne, Christian Ries, Ries, Christian   +9 more
core   +1 more source

Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. [PDF]

PLoS ONE, 2007
Extracellular matrix (ECM) remodeling is important during bone development and repair. Because matrix metalloproteinase 13 (MMP13, collagenase-3) plays a role in long bone development, we have examined its role during adult skeletal repair. In this study
Danielle J Behonick, Zhiqing Xing, Shirley Lieu, Jenni M Buckley, Jeffrey C Lotz, Ralph S Marcucio, Zena Werb, Theodore Miclau, Céline Colnot   +8 more
doaj   +1 more source

Contribution of Matrix Metalloproteinase-9 to Cerebral Edema and Functional Outcome following Experimental Subarachnoid Hemorrhage [PDF]

, 2011
Background: Cerebral edema is an important risk factor for death and poor outcome following subarachnoid hemorrhage (SAH). However, underlying mechanisms are still poorly understood.
Karsten Schöller, Thal, Serge C., Zausinger, Stefan, Schöller, Karsten, Nikolaus Plesnila, Serge C. Thal, Stefan Zausinger, Feiler, Sergej, Plesnila, Nikolaus, Sergej Feiler   +9 more
core   +1 more source

Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival [PDF]

, 2009
Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited.
Braun, Thomas, Besig, Sophie, Baur, Dorothee M., Prinz, Christian, Rad, Roland, Hoefler, Heinz, Höfler, Heinz, Voland, Petra, Perren, Aurel, Langer, Rupert   +9 more
core   +1 more source

Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium [PDF]

Arthritis & Rheumatism, 1997
AbstractObjective. To show the eventual presence and extent of production of matrix metalloproteinase 13 (MMP‐13, or collagenase 3) in rheumatoid synovial tissue samples and extracts, and to assess the inhibition characteristics of recombinant MMP‐13.Methods.
O, Lindy, Y T, Konttinen, T, Sorsa, Y, Ding, S, Santavirta, A, Ceponis, C, López-Otín   +6 more
openaire   +2 more sources

Selective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesions

Molecular Imaging and Biology, 2021
Overexpression and activation of matrix metalloproteinase-13 (MMP-13) within atheroma increases susceptibility to plaque rupture, a major cause of severe cardiovascular complications. In comparison to pan-MMP targeting [18F]BR-351, we evaluated the potential for [18F]FMBP, a selective PET radiotracer for MMP-13, to detect extracellular matrix (ECM ...
Ariel Buchler, Maxime Munch, Gedaliah Farber, Xiaoling Zhao, Rami Al-Haddad, Eadan Farber, Benjamin H. Rotstein   +6 more
openaire   +3 more sources

Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis [PDF]

, 2014
Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches.
Sandhu, G, Christopher H. Woelk, Carlton A. W. Evans, Gurjinder Sandhu (161147), Borislav D. Dimitrov (687966), Gurjinder Sandhu, Woelk Christopher H., Liku B. Tezera, Akul Singhania, Thomas, Richard, Agranoff Dan, Sandhu Gurjinder, Liku B. Tezera (405129), Paul T. Elkington, Christopher H. Woelk (195217), Tezera, LB, Friedland Jon S., Jon S Friedland, Sathyamoorthy, Tarangini, Dimitrov, Borislav D., Sathyamoorthy, T, Singhania, A, Elkington, Paul T., Evans Carlton A. W., Agranoff, Dan, Evans, CAW, Richard Thomas, Elkington Paul T., Dimitrov, BD, Borislav D Dimitrov, Friedland, Jon S., Carlton A. W. Evans (687967), Christopher H Woelk, Dan Agranoff, Paul T Elkington, Paul T. Elkington (364501), Tarangini Sathyamoorthy (687964), Agranoff, D, Jon S. Friedland (161158), Tezera, Liku B., Sathyamoorthy Tarangini, Woelk, Christopher H., Borislav D. Dimitrov, Richard Thomas (687965), Akul Singhania (502117), Evans, Carlton A.W., Singhania, Akul, Jon S. Friedland, Tarangini Sathyamoorthy, Liku B Tezera, Sandhu, Gurjinder, Friedland, JS, Carlton A W Evans, Tezera Liku B., Thomas, R, Elkington, PT, Thomas Richard, Woelk, CH, Singhania Akul, Dan Agranoff (377996), Dimitrov Borislav D.   +60 more
core   +1 more source

Upregulation of MMP-13 and TIMP-1 expression in response to mechanical strain in MC3T3-E1 osteoblastic cells

BMC Research Notes, 2010
Background Mechanical strain plays a significant role in the regulation of bone matrix turnover, which is mediated in part by matrix metalloproteinase (MMP)-13 and tissue inhibitors of matrix metalloproteinase (TIMP)-1. However, little is known about the
Duan Yinzhong, Tang Lin, Li Yongming, Ding Yin   +3 more
doaj   +1 more source

Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats

Journal of Advanced Pharmaceutical Technology & Research, 2019
Prior study has shown that Ageratum conyzoides L. extract that containing quercetin has been proved to prevent inflammation and proteoglycan degradation by inhibiting tumor necrosis factor-alpha and matrix metalloproteinase (MMP-9) expression.
Dian Agustina Permatasari, Deantari Karliana, Iskandarsyah Iskandarsyah, Ade Arsianti, Anton Bahtiar   +4 more
doaj   +1 more source