Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions. [PDF]
Oncotarget, 2016 An exact classification of precancerous stages of colorectal polyps might improve therapy and patients´ outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from patients with cancerous and non-cancerous colorectal adenomas.
Wernicke AK +7 more
europepmc +8 more sources
Matrix metalloproteinase-13 unlucky for the forming thrombus. [PDF]
Res Pract Thromb Haemost, 2018 Matrix metalloproteinases (MMPs) are calcium‐dependent zinc‐containing endoproteases involved in extracellular matrix and non‐matrix protein degradation.1 In the latest issue of Research and Practice in Thrombosis and Haemostasis, Howes and colleagues2 ...
Montague SJ, Gardiner EE.
europepmc +6 more sources
Matrix Metalloproteinase 13 Inhibitors for Modulation of Osteoclastogenesis: Enhancement of Solubility and Stability. [PDF]
ChemMedChem, 2021 AbstractMatrix metalloproteinase 13 (MMP‐13) activity has been correlated to breast cancer bone metastasis. It has been proposed that MMP‐13 contributes to bone metastasis through the promotion of osteoclastogenesis. To explore the mechanisms of MMP‐13 action, we previously described a highly efficacious and selective MMP‐13 inhibitor, RF036 ...
Knapinska AM +7 more
europepmc +3 more sources
Matrix Metalloproteinase‐13 Is an Unfavorable Prognostic Factor in Chordoma by Digesting Growth Inhibitory Collagens [PDF]
Cancer MedicineObjective Chordomas are low‐grade but invasive tumors with limited therapies. Some conventional chordomas exhibit cartilage‐like extracellular matrix (ECM).
Yumiko Oishi +6 more
doaj +2 more sources
Exploring the Genetic Role of Matrix Metalloproteinase-13 Variants in Pterygium Risk. [PDF]
In VivoPterygium is a common ocular surface disorder characterized by abnormal fibrovascular growth and extracellular matrix remodeling, yet its precise molecular etiology remains unclear. Matrix metalloproteinases (MMPs) have been implicated in pterygium pathogenesis.
Chen HC +8 more
europepmc +4 more sources
Matrix Metalloproteinase 13 Activity is Required for Normal and Hypoxia-Induced Precocious Hatching in Zebrafish Embryos [PDF]
Journal of Developmental Biology, 2020 Hypoxia induces precocious hatching in zebrafish, but we do not have a clear understanding of the molecular mechanisms regulating the activation of the hatching enzyme or how these mechanisms trigger precocious hatching under unfavorable environmental ...
Christopher D. Small +4 more
doaj +2 more sources
A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression [PDF]
Journal of NanobiotechnologyRNA interference (RNAi) and oxidative stress inhibition therapeutic strategies have been extensively utilized in the treatment of osteoarthritis (OA), the most prevalent degenerative joint disease.
Qiuyang Wang +8 more
doaj +2 more sources
Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice [PDF]
Scientific Reports, 2018 Cartilage loss in osteoarthritis (OA) results from altered local production of growth factors and metalloproteases (MMPs). Furin, an enzyme involved in the protein maturation of MMPs, might regulate chondrocyte function.
Hilène Lin +8 more
doaj +2 more sources
Matrix Metalloproteinase 13 from Satellite Cells is Required for Efficient Muscle Growth and Regeneration [PDF]
Cellular Physiology and Biochemistry, 2020 Lucas R. Smith +8 more
doaj +2 more sources
Comparison of Elaeagnus angustifolia L. extract and quercetin on mouse model of knee osteoarthritis
Journal of Ayurveda and Integrative Medicine, 2022 Osteoarthritis (OA) is the most commonly observed arthritic disease causing severe pain and impairing patient's quality of life. This study aimed to investigate and compare the effect of Elaeagnus angustifolia extract and quercetin on the mouse model of ...
Mitra Heydari Nasrabadi +3 more
doaj +1 more source